Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events.
Amparo L. Figueroa,Amr Abdelbaky,Quynh A. Truong,Erin M. Corsini,Megan H. MacNabb,Zachary R Lavender,Meredith A Lawler,Steven K. Grinspoon,Thomas J. Brady,Khurram Nasir,Udo Hoffmann,Ahmed Tawakol +11 more
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TLDR
Arterial FDG uptake, measured from routinely obtained PET/CT images, substantially improved incident CVD prediction beyond FRS among individuals undergoing cancer surveillance and provided information on the potential timing of such events.Abstract:
Objectives This study sought to determine whether arterial inflammation measured by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) improves prediction of cardiovascular disease (CVD) beyond traditional risk factors. Background It is unknown whether arterial 18F-FDG uptake measured with routine PET imaging provides incremental value for predicting CVD events beyond Framingham risk score (FRS). Methods We consecutively identified 513 individuals from 6,088 patients who underwent 18F-FDG-PET and computed tomography (CT) imaging at Massachusetts General Hospital between 2005 and 2008 and who met additional inclusion criteria: ≥30 years of age, no prior CVD, and free of cancer. CVD events were independently adjudicated, while blinded to clinical data, using medical records to determine incident stroke, transient ischemic attack, acute coronary syndrome, revascularization, new-onset angina, peripheral arterial disease, heart failure, or CVD death. FDG uptake was measured in the ascending aorta (as target-to-background-ratio [TBR]), while blinded to clinical data. Results During follow-up (median 4.2 years), 44 participants developed CVD (2 per 100 person-years at risk). TBR strongly predicted subsequent CVD independent of traditional risk factors (hazard ratio: 4.71; 95% confidence interval [CI]: 1.98 to 11.2; p Conclusions Arterial FDG uptake, measured from routinely obtained PET/CT images, substantially improved incident CVD prediction beyond FRS among individuals undergoing cancer surveillance and provided information on the potential timing of such events.read more
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Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study
Ahmed Tawakol,Amorina Ishai,Richard A.P. Takx,Amparo L. Figueroa,Abdelrahman Ali,Yannick Kaiser,Quynh A. Truong,Chloe Je Solomon,Claudia Calcagno,Venkatesh Mani,Cheuk Y. Tang,Willem J. M. Mulder,James W. Murrough,Udo Hoffmann,Matthias Nahrendorf,Lisa M. Shin,Zahi A. Fayad,Roger K. Pitman +17 more
TL;DR: In this first study to link regional brain activity to subsequent cardiovascular disease, amygdalar activity independently and robustly predicted cardiovascular disease events.
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PET imaging of inflammation in atherosclerosis
TL;DR: Several novel PET tracers designed to track inflammation, hypoxia, neoangiogenesis, or active calcification, which are all precursors to plaque rupture and its clinical sequelae have been tested in atherosclerosis imaging.
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Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions.
Paolo Raggi,Jacques Genest,Jon T. Giles,Katey J. Rayner,Girish Dwivedi,Rob S. Beanlands,Milan Gupta +6 more
TL;DR: The pathophysiologic contribution of inflammation to atherosclerosis, biomarkers of inflammation and the evidence collected in observational studies regarding the role of chronic inflammation in the development of atherosclerotic heart disease are reviewed.
Journal ArticleDOI
Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis
Jan Bucerius,Fabien Hyafil,Hein J. Verberne,Riemer H. J. A. Slart,Oliver Lindner,Roberto Sciagrà,Denis Agostini,Christopher Übleis,Alessia Gimelli,Marcus Hacker +9 more
TL;DR: This EANM position paper might indeed be a first step towards "official" guidelines on atherosclerosis imaging with PET, which should provide a basis for standardized clinical Atherosclerosis PET imaging protocols, which are subject to further and continuing improvement.
Journal ArticleDOI
Inflammation, immune activation, and cardiovascular disease in HIV.
TL;DR: The evidence describing the relationship between inflammation and cardiovascular disease is summarized and potential anti-inflammatory treatment options for cardiometabolic disease in people living with HIV are discussed.
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