Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Yeon Sik Hong,Su Jin Moon,Young Bin Joo,Chan Hong Jeon,Mi La Cho,Ji Hyeon Ju,Hye Jwa Oh,Yu-Jung Heo,Sung Hwan Park,Ho-Youn Kim,Jun-Ki Min +10 more
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TLDR
IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA, and the levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA.Abstract:
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naive RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.read more
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References
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Journal ArticleDOI
IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice
Waldiceu A. Verri,Ana Tereza Gomes Guerrero,Sandra Y. Fukada,Daniel A. Valério,Thiago M. Cunha,Damo Xu,Sérgio H. Ferreira,Foo Y. Liew,Fernando Q. Cunha +8 more
TL;DR: It is demonstrated that methylated BSA (mBSA) induced hypernociception via the IL-33 → TNFα → IL-1β → IFNγ → ET-1 → PGE2 signaling cascade, revealing a hitherto unrecognized function of IL- 33 in a key immune pharmacological pathway that may be amenable to therapeutic intervention.
Journal ArticleDOI
A Novel Therapy of Murine Collagen-Induced Arthritis with Soluble T1/ST2
TL;DR: Treatment with sST2-Fc markedly inhibited the ability of human monocytic THP1 cells to release TNF-α when cocultured with peripheral blood T cells from rheumatoid patients.
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Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis.
Yasushi Matsuyama,Hitoaki Okazaki,Hiroyuki Tamemoto,Hirotaka Kimura,Yasuyuki Kamata,Katsuya Nagatani,Takao Nagashima,Morisada Hayakawa,Masahiro Iwamoto,Taku Yoshio,Shin-ichi Tominaga,Seiji Minota +11 more
TL;DR: IL-33 levels were elevated in sera and SF samples from patients with RA, and correlated with disease activity; IL-33/ST2L signaling might play an important role in joint inflammation of human RA.
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Identification of human ST2 protein in the sera of patients with autoimmune diseases.
TL;DR: The experiments using gel filtration and SDS-PAGE under a nonreducing condition indicated the existence of the ST2 multimer in serum, and the mobility of the natural protein was slower than that of the recombinant human ST2 protein produced by COS7 cells in SDS -PAGE, suggesting a difference of glycosylation between humans and monkeys.
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T1/ST2—an IL-1 receptor-like modulator of immune responses
TL;DR: The mechanisms and therapeutic implications of the unique ability of ST2 to promote development and function of type 2 helper T cells through a positive feedback loop, as well as to act as a negative feedback modulator of macrophage pro-inflammatory function are analyzed.