Measurement of portal pressure and its clinical application
TL;DR: It is still uncertain whether portal pressure is useful in predicting variceal bleeding, but two groups of investigators have recently shown that wedged hepatic vein pressure and portal vein pressure are essentially identical in alcoholic liver disease and probably in cryptogenic cirrhosis and chronic active hepatitis.
About: This article is published in The American Journal of Medicine.The article was published on 1970-11-01. It has received 149 citations till now. The article focuses on the topics: Portal venous pressure & Portal hypertension.
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TL;DR: The effects of propranolol on blood flow through gastroesophageal collaterals and on systemic and hepatic hemodynamies were investigated and azygos venous blood flow was markedly increased in patients with portal hypertension.
290 citations
TL;DR: Assessment of hemodynamic response to drugs in terms of HVPG is the best predictor of efficacy of prophylaxis of variceal bleeding in patients treated with beta‐blockers or beta-blockers plus nitrates.
252 citations
TL;DR: Close agreement was found between portal vein pressure and wedged hepatic vein pressure in quiescent alcoholic liver disease and alcoholic hepatitis, indicating a presinusoidal component to the portal hypertension.
243 citations
TL;DR: The balloon technique offers many advantages over the conventional approach, including the ease of achieving and demonstrating the wedged position from the femoral approach, the ability to measure the free and wedged pressure repeatedly without manipulating the catheter, and the measurement of pressure in a larger, more representative segment of the liver.
227 citations
TL;DR: Investigation of the effect of nitroglycerin on splanchnic and systemic hemodynamics in cirrhotic patients and portal hypertensive dogs and in dogs provides evidence that the addition of nitreglycerin to an i.v. infusion of vasopressin reversed the detrimental effects of vasipressin while preserving the beneficial effects.
221 citations
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Book•
01 Jan 1968
TL;DR: Diseases of the liver and biliary system is studied to find out the main mechanisms leading to liver failure and its role in cirrhosis.
Abstract: Diseases of the liver and biliary system , Diseases of the liver and biliary system , کتابخانه دیجیتال جندی شاپور اهواز
1,730 citations
TL;DR: Whether or not the Australia antigen represents a virus remains to be established; nonetheless, identification of this antigen in the serum of hepatitis patients constitutes a fascinating development that may, hopefully, presage eradication of transfusion-induced hepatitis.
Abstract: Whether or not the Australia antigen represents a virus remains to be established; nonetheless, identification of this antigen in the serum of hepatitis patients constitutes a fascinating development that may, hopefully, presage eradication of transfusion-induced hepatitis. Other recent developments discussed by the 51 contributors to Popper and Schaffner's book range from hepatic culture and transplantation to umbilical vein catheterization and phototherapy. Intense blue light, according to Hsia and Porto, decomposes the bilirubin in icteric serum and sometimes controls neonatal jaundice. They caution, however, against an ill effect from the degradation products. Reporting on another development, Chiandussi tells how to catheterize the umbilical vein. Umbilico-portal catheterization, he notes, permits selective splenic and portal phlebography, measurement of direct portal venous pressure, and decompression of the portal bed during hemorrhage from esophageal varices. He also notes that a physician can use the transumbilical catheter to infuse chemotherapeutic agents directly into a cancerous liver.
533 citations
213 citations
TL;DR: Patients with cirrhosis and esophageal varices participated in a controlled prospective investigation of the prophylactic portacaval shunt procedure for the prevention of blee...
208 citations