Journal ArticleDOI
Measurement of Viscoelastic Properties of Polyacrylamide-Based Tissue-Mimicking Phantoms for Ultrasound Elastography Applications
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TLDR
Polyacrylamide gel based tissue-mimicking phantoms have been developed to experimentally study the role of viscoelastic properties inPhantoms and indicate that stiffer samples exhibit large variations in the storage modulus when the precompression levels are altered.Abstract:
Many ailments and/or malfunctions of the body have been observed to change the viscous behavior and elastic properties of biological soft tissues. The technique of elastography has evolved to image such properties. The clinical evidence gathered during studies involving elastography to identify cancerous lesions is very promising. However, the quantification of the resolution and specificity of elastography is best achieved under a controlled study using tissue-mimicking phantoms. One challenge is to reproduce viscoelastic behavior in phantoms as observed in biological tissues. In this paper, polyacrylamide gel based tissue-mimicking phantoms have been developed to experimentally study the role of viscoelastic properties in a controlled manner. To measure the Young's modulus, the phantoms were subjected to linear loading, and the stress-strain relationship is deduced therefrom. It is seen that the phantoms show hysteresis behavior. The viscoelastic properties of these phantoms were measured by subjecting the samples to cyclic loading. Normal forces during this process of loading were also measured as a measure of sample elasticity. To emulate the normal and pathological lesions, samples were prepared with varying concentration of monomer and studied. Three models, namely, Maxwell, Kelvin-Voigt (KV), and Kelvin-Voigt fractional derivative (KVFD), were chosen to fit the experimental data. Of these, the KVFD model was found to be best fitting for the experimental data obtained. Results indicate that stiffer samples exhibit large variations in the storage modulus when the precompression levels are altered.read more
Citations
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Journal ArticleDOI
Optical coherence elastography: current status and future applications.
TL;DR: OCE techniques, including the development of intravascular- or catheter-based OCE, are in their early stages of development but show great promise for surgical oncology or intrav vascular cardiology applications.
Journal ArticleDOI
Vibration and instability of a viscous-fluid-conveying single-walled carbon nanotube embedded in a visco-elastic medium
TL;DR: In this paper, the transverse vibrational model of a viscous-fluid-conveying single-walled carbon nanotube (SWCNT) embedded in biological soft tissue is developed.
Journal ArticleDOI
A Frequency-Shift Method to Measure Shear-Wave Attenuation in Soft Tissues
TL;DR: The frequency-shift method, used in ultrasound imaging and seismology, was adapted for shear-wave attenuation measurement in elastography, and provides tissue attenuation, which is relevant diagnostic information to model viscosity, in addition to sheer-wave velocity used to assess elasticity.
Journal ArticleDOI
Nonlinear vibration and instability of fluid-conveying DWBNNT embedded in a visco-Pasternak medium using modified couple stress theory
TL;DR: In this paper, the effects of the transverse shear deformation and rotary inertia are considered by utilizing the Timoshenko beam theory and considering a material length scale parameter for beam model.
Journal ArticleDOI
Acoustic and Elastic Properties of Glycerol in Oil-Based Gel Phantoms
Luciana C. Cabrelli,Felipe Wilker Grillo,Diego R. T. Sampaio,Antonio A. O. Carneiro,Theo Z. Pavan +4 more
TL;DR: Glycerol dispersion in oil-based gels is proposed to modify the acoustic and elastic properties of copolymer-in-oil phantoms and opens the possibility of incorporating other oil-insoluble substances to control further properties of the phantom.
References
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Journal ArticleDOI
Supersonic shear imaging: a new technique for soft tissue elasticity mapping
TL;DR: The first in vivo investigations made on healthy volunteers emphasize the potential clinical applicability of SSI for breast cancer detection and results validating SSI in heterogeneous phantoms are presented.
Journal ArticleDOI
Elastic Moduli of Breast and Prostate Tissues under Compression
TL;DR: To evaluate the dynamic range of tissue imaged by elastography, the mechanical behavior of breast and prostate tissue samples subject to compression loading has been investigated and the data show that breast fat tissue has a constant modulus over the strain range tested while the other tissues have a modulus that is dependent on the strain level.
Journal ArticleDOI
A Theoretical Basis for the Application of Fractional Calculus to Viscoelasticity
Ronald L. Bagley,Peter J. Torvik +1 more
TL;DR: In this article, the authors established a link between molecular theories that predict the macroscopic behavior of certain viscoelastic media and an empirically developed fractional calculus approach to visco-elasticity.
Journal ArticleDOI
Breast disease: clinical application of US elastography for diagnosis.
Ako Itoh,Ei Ueno,Eriko Tohno,Hiroshi Kamma,Hideto Takahashi,Tsuyoshi Shiina,Makoto Yamakawa,Takeshi Matsumura +7 more
TL;DR: For assessing breast lesions, US elastography with the proposed imaging classification, which was simple compared with that of the Breast Imaging Recording and Data System classification, had almost the same diagnostic performance as conventional US.