Journal ArticleDOI
Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material.
R. Glynn Holt,Ronald A. Roy +1 more
Reads0
Chats0
TLDR
Evidence for the hypothesis that cavitation bubble activity in the focal zone is the cause of enhanced heating is presented and discussed, and mechanisms for bubble-assisted heating are presented and modeled, and quantitative estimates for the thermal power generated by viscous dissipation and bubble acoustic radiation are given.Abstract:
Time-resolved measurements of the temperature field in an agar-based tissue-mimicking phantom insonated with a large aperture 1-MHz focused acoustic transducer are reported. The acoustic pressure amplitude and insonation duration were varied. Above a critical threshold acoustic pressure, a large increase in the temperature rise during insonation was observed. Evidence for the hypothesis that cavitation bubble activity in the focal zone is the cause of enhanced heating is presented and discussed. Mechanisms for bubble-assisted heating are presented and modeled, and quantitative estimates for the thermal power generated by viscous dissipation and bubble acoustic radiation are given.read more
Citations
More filters
Journal ArticleDOI
High intensity focused ultrasound: physical principles and devices.
TL;DR: The principle of operation of high intensity focused ultrasound, a treatment modality enabling non-invasive tissue heating and ablation for numerous applications, and numerous extra-corporeal, transrectal and interstitial devices have been described here to optimise application-specific treatment delivery.
Journal ArticleDOI
Therapeutic applications of ultrasound.
TL;DR: Therapeutic applications of ultrasound predate its use in imaging, but useful therapeutic effects are now being demonstrated clinically, the mechanisms by which they occur are often not well understood.
Journal ArticleDOI
Ultrasound—biophysics mechanisms
TL;DR: In this article, the authors discuss the mechanisms responsible for how ultrasound and biological materials interact and discuss the risk of exposure to these mechanisms in the context of diagnostic ultrasound exposure risk concerns.
Journal ArticleDOI
Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery
TL;DR: It is shown that inertial cavitation can help address some of the major challenges of HIFU therapy by providing a means of enhancing and monitoring treatment noninvasively.
Journal ArticleDOI
Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU)
TL;DR: Models for how different types of cavitation activity can serve to accelerate tissue heating are presented, and results suggest that the bulk of the enhanced heating effect can be attributed to the absorption of broadband acoustic emissions generated by inertial cavitation.
References
More filters
Book
The Acoustic Bubble
TL;DR: In this article, the authors present a bibliographie (a la fin de chaque chapitre), and index reference record created on 2004-09-07, modified on 2016-08-08
Journal ArticleDOI
Comprehensive compilation of empirical ultrasonic properties of mammalian tissues
TL;DR: A detailed review of the literature on ultrasonic propagation properties of mammalian tissues and organs has revealed 144 papers containing compilable data, including over 1300 lines of parametric data.
Journal ArticleDOI
Bubble Oscillations of Large Amplitude
TL;DR: In this paper, a new equation was derived for large amplitude forced radial oscillations of a bubble in an incident sound field, including the effects of acoustic radiation, as in Keller and Kolodner's equation.
Journal ArticleDOI
Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound.
TL;DR: An index is developed which can gauge the likelihood of substantial microbubble growth in the presence of short-pulse, low-duty cycle diagnostic ultrasound.
Journal ArticleDOI
Demonstration of Potential Noninvasive Ultrasound Brain Therapy Through an Intact Skull
TL;DR: Results showed that transcranial delivery of therapeutic ultrasound into the brain may be feasible and tissue destruction was induced by using pulsed sonication through a piece of human skull in a rabbit brain in vivo.