Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things
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This work aims to provide a history of canine coronavirus infection in the context of central giant cell granuloma and aims to establish a cause-and-effect relationship between infection and disease progression.About:
This article is published in Cell.The article was published on 1998-02-06 and is currently open access. It has received 1163 citations till now. The article focuses on the topics: Spliceosomal complex & Prespliceosome.read more
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Mechanisms of Alternative Pre-Messenger RNA Splicing
TL;DR: This review describes what is currently known of the molecular mechanisms that control changes in splice site choice and starts with the best-characterized systems from the Drosophila sex determination pathway, and then describes the regulators of other systems about whose mechanisms there is some data.
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The Spliceosome: Design Principles of a Dynamic RNP Machine
TL;DR: The spliceosome exhibits exceptional compositional and structural dynamics that are exploited during substrate-dependent complex assembly, catalytic activation, and active site remodeling in the pre-mRNAs.
Journal ArticleDOI
The noncoding RNA revolution-trashing old rules to forge new ones.
TL;DR: The pathway of ncRNA research is described, where every established "rule" seems destined to be overturned.
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Spliceosome structure and function.
Cindy L. Will,Reinhard Lührmann +1 more
TL;DR: The extensive interplay of RNA and proteins in aligning the pre-mRNA's reactive groups, and the presence of both RNA and protein at the core of the splicing machinery, suggest that the spliceosome is an RNP enzyme, but elucidation of the precise nature of its active site awaits the generation of a high-resolution structure of its RNP core.
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The cell as a collection of protein machines : preparing the next generation of molecular biologists
TL;DR: Underlying this highly organized activity are Orders A and B, which describe the “politics of science” as a kind of social contract.
References
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Spliced segments at the 5' terminus of adenovirus 2 late mRNA
TL;DR: Four segments of viral RNA may be joined together during the synthesis of mature hexon mRNA, a model is presented for adenovirus late mRNA synthesis that involves multiple splicing during maturation of a larger precursor nuclear RNA.
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Helicases: amino acid sequence comparisons and structure-function relationships
TL;DR: Three large superfamilies and two smaller families of helicases are described and experimental results support the value of the conserved motifs for prediction of structure and function of the helicases.
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An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
TL;DR: Findings imply a new mechanism for the biosynthesis of Ad2 mRNA in mammalian cells which is complementary to sequences within the Ad2 genome which are remote from the DNA from which the main coding sequence of each mRNA is transcribed.
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A general two-metal-ion mechanism for catalytic RNA
Thomas A. Steitz,Joan A. Steitz +1 more
TL;DR: The mechanism postulates that chemical catalysis is facilitated by two divalent metal ions 3.9 A apart, as in phosphoryl transfer reactions catalyzed by protein enzymes, such as the 3',5'-exonuclease of Escherichia coli DNA polymerase I.