Book ChapterDOI
Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pests
Alejandra Bravo,Diana L. Martínez de Castro,Jorge Sánchez,Pablo Emiliano Cantón,Gretel Mendoza,Isabel Gómez,Sabino Pacheco,Blanca I. García-Gómez,Janette Onofre,Josue Ocelotl,Mario Soberón +10 more
- pp 858-873
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TLDR
The great diversity of BT toxins represents a broad opportunity to control the most important insect pests that affect different crops, as well as vectors of human diseases such as malaria and dengue, and to design strategies to manage the development of insect resistance to Bt toxins.Abstract:
Bacillus thuringiensis (Bt) bacteria synthesize different insecticidal proteins named Cry, Vip, and Cyt that are able to kill different insect orders, or nematodes. These proteins have been extensively used in insect control practices in agriculture as sprays or expressed in genetically modified plants. This chapter reviews the mechanism of action of these Bt proteins. In addition, genetic engineering has proven to help in developing novel biotechnological applications of these toxins, such as Cry1AMod toxins, which are active against insects that have developed resistance to Cry toxins; and zymogen-like Vip2 proteins, which can be used to control specific insect pests. Overall, the great diversity of Bt toxins represents a broad opportunity to control the most important insect pests that affect different crops, as well as vectors of human diseases such as malaria and dengue, and to design strategies to manage the development of insect resistance to Bt toxins.read more
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Journal ArticleDOI
Use of botanical insecticides for sustainable agriculture: Future perspectives
Estefânia Vangelie Ramos Campos,Estefânia Vangelie Ramos Campos,Patrícia L. F. Proença,Jhones Luiz de Oliveira,Mansi Bakshi,Purushothaman Chirakkuzhyil Abhilash,Leonardo Fernandes Fraceto +6 more
TL;DR: In this paper, the authors discuss perspectives for the use of compounds of botanical origin, as well as strategies employing the encapsulation techniques that can contribute to the development of systems for use in sustainable agricultural practices.
Journal ArticleDOI
The Cytocidal Spectrum of Bacillus thuringiensis Toxins: From Insects to Human Cancer Cells.
Gretel Mendoza-Almanza,Edgar L. Esparza-Ibarra,Jorge Luis Ayala-Lujan,Marisa Mercado-Reyes,Susana Godina-González,Marisa Hernández-Barrales,Jorge Olmos-Soto +6 more
TL;DR: It was recently demonstrated that SLP produced by Bt could interact with membrane receptors of insect and human cancer cells to kill them, and Cyt toxins have a structure that is mostly unrelated to Cry toxins; thereby, other mechanisms of action have been reported to them.
Journal ArticleDOI
Characteristics of Bacillus thuringiensis isolates indigenous soil of South Sumatra (Indonesia) and their pathogenicity against oil palm pests Oryctes rhinoceros (Coleoptera: Scarabaeidae)
TL;DR: B. thuringiensis is a gram-positive, entomopathogenic bacterium that could be isolated from soil and be used to control various plant pests and it was found to be effective in killing O. rhinoceros larvae.
Journal ArticleDOI
Trypsin inhibitor from Enterolobium contortisiliquum seeds impairs Aedes aegypti development and enhances the activity of Bacillus thuringiensis toxins
Pedro M S Tabosa,Luiz Carlos Pereira Almeida Filho,Rute X Franca,Lady C.B. Rocha-Bezerra,Ilka M. Vasconcelos,Ana Fontenele Urano Carvalho +5 more
TL;DR: The results offer a novel approach by combining EcTI and B. thuringiensis toxins for combating Ae.
References
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Journal ArticleDOI
Bacillus thuringiensis and Its Pesticidal Crystal Proteins
E. Schnepf,Neil Crickmore,J. Van Rie,Didier Lereclus,J. Baum,Jerald S. Feitelson,Daniel R. Zeigler,Donald H. Dean +7 more
TL;DR: Researchers are reporting promising results in engineering more-useful toxins and formulations, in creating transgenic plants that express pesticidal activity, and in constructing integrated management strategies to insure that these products are utilized with maximum efficiency and benefit.
Journal ArticleDOI
Yield Effects of Genetically Modified Crops in Developing Countries
TL;DR: Onfarm field trials carried out with Bacillus thuringiensis (Bt) cotton in different states of India show that the technology substantially reduces pest damage and increases yields.
Journal ArticleDOI
Vip3A, a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects.
Juan Jose Estruch,Gregory W. Warren,Martha A. Mullins,Gordon J. Nye,Joyce A. Craig,Michael G. Koziel +5 more
TL;DR: Vip3A represents a novel class of proteins insecticidal to lepidopteran insect larvae, whose expression is restricted to sporulation, and which is expressed in the vegetative stage of growth starting at mid-log phase as well as during sporulation.
Journal ArticleDOI
Role of Receptors in Bacillus thuringiensis Crystal Toxin Activity
Craig R. Pigott,David J. Ellar +1 more
TL;DR: This review analyzes the interactions between Cry toxins and their receptors, focusing on the identification and validation of receptors, the molecular basis for receptor recognition, the role of the receptor in resistant insects, and proposed models to explain the sequence of events at the cell surface by which receptor binding leads to cell death.