Mechanisms of Angiogenesis Process after Pancreatic Islet Cell Transplantation: Role of Intra-islet Endothelial Cells
Siddharth Narayanan,Gopalakrishnan Loganathan,Maheswaran Dhanasekaran,William W. Tucker,Ankit Patel,Venugopal Subhashree,Sri Prakash Mokshagundam,Michael J Hughes,Stuart K. Williams,Appakalai N. Balamurugan +9 more
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TLDR
Using pancreatic islets as a model for vascularized tissue, a general overview of EC behaviour dynamics in sprouting angiogenesis is presented, particularly focusing on the interplay between VEGF and Notch pathways.Abstract:
Angiogenic sprouting is a complex, multi-step process involving highly integrated cell behaviours, initial interaction with the environment and signalling pathways. Endothelial cells (ECs) are central to the angiogenic process, with recent insights establishing how these cells communicate with each other and with their microenvironment to form branched vascular networks. Using pancreatic islets as a model for vascularized tissue, this review will present a general overview of EC behaviour dynamics in sprouting angiogenesis, particularly focusing on the interplay between VEGF and Notch pathways. A better understanding of molecular mechanisms associated with intra-islet EC cross-talk and its micro-environment may present exciting new perspectives on islet graft to host revascularization and in supporting islet graft survival.read more
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Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells
Marco Farina,Marco Farina,Corrine Ying Xuan Chua,Andrea Ballerini,Usha Thekkedath,Jenolyn F. Alexander,Jessica Rhudy,Gianluca Torchio,Daniel W. Fraga,Ravi Ramesh Pathak,Mariana Villanueva,Crystal S. Shin,Jean A. Niles,Raffaella Sesana,Danilo Demarchi,Andrew G. Sikora,Ghanashyam Acharya,A. Osama Gaber,Joan E. Nichols,Alessandro Grattoni +19 more
TL;DR: The promising results provide a proof of concept for the NICHE as a viable platform technology for autologous cell transplantation for the treatment of a variety of diseases.
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Development of the human pancreas and its vasculature — An integrated review covering anatomical, embryological, histological, and molecular aspects
Brandon Michael Henry,Bendik Skinningsrud,Karolina Saganiak,Przemysław A. Pękala,Jerzy A. Walocha,Krzysztof A. Tomaszewski +5 more
TL;DR: A comprehensive overview of the clinically relevant anatomical and histological aspects of the development of the human pancreas, with emphasis on the vascularization of the gland was provided in this article.
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Endothelial cell regulation through epigenetic mechanisms: Depicting parallels and its clinical application within an intra-islet microenvironment.
Siddharth Narayanan,Gopalakrishnan Loganathan,Sri Prakash Mokshagundam,Michael G. Hughes,Stuart K. Williams,Appakalai N. Balamurugan +5 more
TL;DR: This review will present an overview of the reports involving endothelial epigenetic mechanisms particularly focusing on histone modifications which have been identified to play a critical role in governing EC functions by modifying the chromatin structure.
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