Open AccessJournal Article
Mechanisms of bile formation, hepatic uptake, and biliary excretion.
Curtis D. Klaassen,J B Watkins +1 more
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This article is published in Pharmacological Reviews.The article was published on 1984-03-01 and is currently open access. It has received 388 citations till now. The article focuses on the topics: Enterohepatic circulation & Cholestasis.read more
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Mammalian ABC Transporters in Health and Disease
Piet Borst,R.P.J. Oude Elferink +1 more
TL;DR: This work focuses on three topics: ABC transporters transporting drugs (xenotoxins) and drug conjugates, and a rapidly increasing number of ABC Transporters found to play a role in lipid transport.
Journal ArticleDOI
Pharmacokinetics and dosage adjustment in patients with renal dysfunction
TL;DR: It is shown that renal dysfunction affects more that just the renal handling of drugs and/or active drug metabolites, and a re-evaluation of markers of renal function may be required, even when the dosage adjustment recommended for patients with renal dysfunction are carefully followed.
Journal ArticleDOI
Enterohepatic circulation: physiological, pharmacokinetic and clinical implications.
TL;DR: Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation, and may prolong the pharmacological effect of certain drugs and drug metabolites.
OtherDOI
Bile formation and secretion.
TL;DR: Canalicular bile secretion is determined by both bile salt-dependent and independent transport systems which are localized at the apical membrane of the hepatocyte and largely consist of a series of adenosine triphosphate-binding cassette transport proteins that function as export pumps for bile salts and other organic solutes.