Mechanisms of central tolerance for B cells
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TLDR
Mechanistic studies have begun to elucidate how divergent mechanisms that regulate tolerance are controlled, and single-cell antibody cloning has revealed defects of B cell central tolerance in human autoimmune diseases and in several human immunodeficiency diseases caused by single gene mutations.Abstract:
Receptor editing and apoptosis have crucial roles in promoting the central tolerance of B cells to self-antigens. Defects of these processes can result in autoimmunity or immunodeficiency disease in humans and mice.read more
Citations
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Analysis of the B cell receptor repertoire in six immune-mediated diseases.
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References
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Hedda Wardemann,Sergey Yurasov,Sergey Yurasov,Anne Schaefer,James W. Young,Eric Meffre,Eric Meffre,Michel C. Nussenzweig,Michel C. Nussenzweig +8 more
TL;DR: The prevalence of self-reactive antibody formation and its regulation in human B cells is determined and a majority (55 to 75%) of all antibodies expressed by early immature B cells displayedSelf-reactivity, including polyreactive and anti-nuclear specificities.
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Somatic Generation of Antibody Diversity1
TL;DR: In this paper, it was shown that an organism does not inherit even a single complete gene for antibody polypeptide chains, rather, the genetic information is transmitted in germline as no more than several hundred gene segments.
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C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity
TL;DR: C3d is a molecular adjuvant of innate immunity that profoundly influences an acquired immune response and is found to differentiate between harmful and innocuous antigens.