Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein
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TLDR
This review discusses coronavirus entry mechanisms focusing on the different triggers used by coronaviruses to initiate the conformational change of the S protein: receptor binding, low pH exposure and proteolytic activation.Citations
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An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Lisa A. Jackson,Evan J. Anderson,Nadine Rouphael,Paul C. Roberts,Mamodikoe Makhene,Rhea N. Coler,Michele Paine McCullough,James D. Chappell,Mark R. Denison,Laura J. Stevens,Andrea J. Pruijssers,Adrian B. McDermott,Britta Flach,Nicole A. Doria-Rose,Kizzmekia S. Corbett,Kaitlyn M. Morabito,Sijy O’Dell,Stephen D. Schmidt,Phillip A. Swanson,Marcelino Padilla,John R. Mascola,Kathleen M. Neuzil,Hamilton Bennett,Wellington Sun,Etza Peters,Mat Makowski,Jim Albert,Kaitlyn Cross,Wendy Buchanan,Rhonda Pikaart-Tautges,Julie E. Ledgerwood,Barney S. Graham,John H. Beigel +32 more
TL;DR: The mRNA-1273 vaccine induced anti-SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified, which support further development of this vaccine.
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Cell entry mechanisms of SARS-CoV-2.
TL;DR: Key cell entry mechanisms of SARS-CoV-2 that potentially contribute to the immune evasion, cell infectivity, and wide spread of the virus are identified using biochemical and pseudovirus entry assays and the potency and evasiveness are highlighted.
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Structure, Function, and Evolution of Coronavirus Spike Proteins.
TL;DR: This article reviews current knowledge about the structures and functions of coronavirus spike proteins, illustrating how the two S1 domains recognize different receptors and how the spike proteins are regulated to undergo conformational transitions.
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Transmission routes of 2019-nCoV and controls in dental practice.
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COVID-19 pathophysiology: A review.
TL;DR: The current knowledge about this disease is reviewed and the potential explanation of the different symptomatology between children and adults is considered.
References
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Coronaviruses post-SARS: update on replication and pathogenesis.
Stanley Perlman,Jason Netland +1 more
TL;DR: This Review focuses on recent advances in the understanding of the mechanisms of coronavirus replication, interactions with the host immune response and disease pathogenesis and the recent identification of numerous novel coronaviruses.
Journal ArticleDOI
The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex
TL;DR: Using biological assays, the HR2 peptide was shown to be a potent inhibitor of virus entry into the cell, as well as of cell-cell fusion.
Journal ArticleDOI
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus
TL;DR: The data gathered on the animal coronaviruses continue to be helpful in understanding SARS-CoV, and the progress in vaccine development and antiviral therapies is discussed.
Journal ArticleDOI
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Graham Simmons,Dhaval N. Gosalia,Andrew J. Rennekamp,Jacqueline D. Reeves,Scott L. Diamond,Paul Bates +5 more
TL;DR: It is demonstrated here that the lysosomotropic-agent-mediated block to SARS-CoV infection is overcome by protease treatment of target-cell-associated virus, and the requirement for cathepsin L proteolysis identifies a previously uncharacterized class of inhibitor for SARS
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