Mechanisms underlying spontaneous patterned activity in developing neural circuits
Reads0
Chats0
TLDR
This research suggests that developing neural circuits exhibit transient and tunable features that maintain a source of correlated activity during crucial stages of development.Abstract:
Patterned, spontaneous activity occurs in many developing neural circuits, including the retina, the cochlea, the spinal cord, the cerebellum and the hippocampus, where it provides signals that are important for the development of neurons and their connections. Despite there being differences in adult architecture and output across these various circuits, the patterns of spontaneous network activity and the mechanisms that generate it are remarkably similar. The mechanisms can include a depolarizing action of GABA (gamma-aminobutyric acid), transient synaptic connections, extrasynaptic transmission, gap junction coupling and the presence of pacemaker-like neurons. Interestingly, spontaneous activity is robust; if one element of a circuit is disrupted another will generate similar activity. This research suggests that developing neural circuits exhibit transient and tunable features that maintain a source of correlated activity during crucial stages of development.read more
Citations
More filters
Journal ArticleDOI
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
TL;DR: A plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention, and implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.
Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
Journal ArticleDOI
Emergence of resting state networks in the preterm human brain
Valentina Doria,Christian F. Beckmann,Tomoki Arichi,Nazakat Merchant,Michela Groppo,Federico Turkheimer,Serena J. Counsell,Maria Murgasova,Paul Aljabar,Rita G. Nunes,David J. Larkman,Geraint Rees,A. David Edwards +12 more
TL;DR: The results place the emergence of RSNs largely during the period of rapid neural growth in the third trimester of gestation, suggesting that they are formed before the acquisition of cognitive competencies in later childhood.
Journal ArticleDOI
Retinal waves coordinate patterned activity throughout the developing visual system
TL;DR: Optical methods are used to show in live neonatal mice that waves of spontaneous retinal activity are present and propagate throughout the entire visual system before eye opening, and carries patterned information capable of guiding the activity-dependent development of complex intra- and inter-hemispheric circuits before the onset of vision.
Journal ArticleDOI
Functional architecture of the retina: Development and disease
TL;DR: Advances in understanding of how cellular and molecular mechanisms act to shape structure and function at the single cell level, to coordinate the assembly of cell populations, and to define their specific circuitry are reviewed.
References
More filters
Journal ArticleDOI
Excitatory actions of gaba during development: the nature of the nurture.
TL;DR: This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.
Journal ArticleDOI
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TL;DR: In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges.
Journal ArticleDOI
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
TL;DR: It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.
Journal ArticleDOI
Synchronous Bursts of Action Potentials in Ganglion Cells of the Developing Mammalian Retina
TL;DR: The development of orderly connections in the mammalian visual system depends on action potentials in the optic nerve fibers, even before the retina receives visual input, and correlated firing of retinal ganglion cells in the same eye directs the segregation of their synaptic terminals into eye-specific layers within the lateral geniculate nucleus.
Journal ArticleDOI
Is there more to gaba than synaptic inhibition
TL;DR: The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal in the immature brain.