Journal ArticleDOI
Mechanochemical organic synthesis
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TLDR
This review article provides a comprehensive overview of various solvent-free mechanochemical organic reactions, including metal-mediated or -catalyzed reactions, condensation reactions, nucleophilic additions, cascade reactions, Diels-Alder reactions, oxidations, reductions, halogenation/aminohalogenation, etc.Abstract:
Recently, mechanical milling using a mixer mill or planetary mill has been fruitfully utilized in organic synthesis under solvent-free conditions This review article provides a comprehensive overview of various solvent-free mechanochemical organic reactions, including metal-mediated or -catalyzed reactions, condensation reactions, nucleophilic additions, cascade reactions, Diels–Alder reactions, oxidations, reductions, halogenation/aminohalogenation, etc The ball milling technique has also been applied to the synthesis of calixarenes, rotaxanes and cage compounds, asymmetric synthesis as well as the transformation of biologically active compoundsread more
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Mechanochemistry: A Force of Synthesis
Jean-Louis Do,Tomislav Friščić +1 more
TL;DR: A brief overview of the recent achievements and opportunities created by mechanochemistry, including access to materials, molecular targets, and synthetic strategies that are hard or even impossible to access by conventional means are provided.
Journal ArticleDOI
Mechanochemistry for Synthesis
TL;DR: This mini-review examines the potential of mechanochemistry in chemical and materials synthesis, by providing a cross-section of the recent developments in using ball milling for the formation of molecules and materials based on covalent and coordination bonds.
Journal ArticleDOI
Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?
TL;DR: Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency, and what more it can offer, aside from the clear benefit of reduced solvent consumption.
Journal ArticleDOI
Altering Product Selectivity by Mechanochemistry
José G. Hernández,Carsten Bolm +1 more
TL;DR: This Perspective highlights a few selected examples that illustrate the value of mechanochemistry in uncovering interesting chemical reactivity, which is often masked in typical liquid-phase synthesis.
Journal ArticleDOI
Mechanochemistry and organic synthesis: from mystical to practical
Joel Andersen,James Mack +1 more
TL;DR: For a review of the state-of-the-art in mechanochemistry, see, e.g., this article, the review presented in this paper. But, there still remains some mystique guarding the "rules" of mechanochemistry.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.
TL;DR: This work over the past several years to form carbon-carbon bonds directly from two different C-H bonds under oxidative conditions, cross-dehydrogenative coupling (CDC) is described, which provides an alternative to the separate steps of prefunctionalization and defunctionsalization that have traditionally been part of synthetic design.
Journal ArticleDOI
Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TL;DR: Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.