Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
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TLDR
Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.Abstract:
The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).read more
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Surface and Bulk Chemistry of Mechanochemically Synthesized Tohdite Nanoparticles
Jacopo de Bellis,Cristina Ochoa-Hernández,Christophe Farès,Hilke Petersen,Jan Ternieden,Claudia Weidenthaler,Amol P. Amrute,Ferdi Schüth +7 more
TL;DR: In this paper , a straightforward methodology to synthesize tohdite nanopowders via the mechanochemically induced dehydration of boehmite (γ-AlOOH) was reported.
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L-Proline catalyzed three component synthesis of pyrano[2,3-c]pyrazole-5-carbonitrile derivatives and in vitro antimalarial evaluation
TL;DR: An efficient one-pot synthesis of 6-amino-4-(2-chloroquinolin-3-yl)-3-methyl-2, 4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile derivatives (4a−f)(5a-f) by three component reactions of 2-chloroquino...
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From isomorphous to “anisomorphous” ionic co-crystals of barbituric acid upon dehydration and return
Lucia Maini,Dario Braga,Fabrizia Grepioni,Giulio I. Lampronti,Katia Gaglioti,Roberto Gobetto,Michele R. Chierotti +6 more
TL;DR: The isomorphous hydrated ionic co-crystals (ICCs) of barbituric acid (BA) of the formula BA·MBr·2H2O (M = Na, K, Rb) can be easily dehydrated to the corresponding anhydrous ICCs BA·KBr and BA·RbBr as discussed by the authors.
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Manipulating Reaction Energy Coordinate Landscape of Mechanochemical Diaza-Cope Rearrangement
TL;DR: In this paper , the additive effect is used to manipulate a reaction pathway in mechanochemical diazo-Cope rearrangement pathway, and this is expected to find broad interest in organic synthesis using mechanical force as an energy input.
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Mechanochemical synthesis, characterization and antimicrobial screening of Metal (II) complexes derived from amoxicillin
TL;DR: The results showed that both the ligand and the complexes are active against three bacterial strains; Escherichia coli, Salmonella typhi and Staphylococcus aureus for antimicrobial activity.
References
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A profile refinement method for nuclear and magnetic structures
TL;DR: In this paper, a structure refinement method was described which does not use integrated neutron powder intensities, single or overlapping, but employs directly the profile intensities obtained from step-scanning measurements of the powder diagram.
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A chemically functionalizable nanoporous material (Cu3(TMA)2(H2O)3)n
TL;DR: In this paper, a highly porous metal coordination polymer [Cu3(TMA)2(H2O)3]n (where TMA is benzene-1,3,5-tricarboxylate) was formed in 80 percent yield.
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The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla,Carmen Nájera +1 more
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
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Asymmetric enamine catalysis.
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Rietveld refinement guidelines
TL;DR: A set of general guidelines for structure refinement using the Rietveld (whole profile) method has been formulated by the International Union of Crystallography Commission on Powder Diffraction.