Journal ArticleDOI
Mechanosensation and transduction in osteocytes
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TLDR
This review highlights current insights in bone adaptation to external mechanical loading, with an emphasis on how a mechanical load placed on whole bones is translated and amplified into a mechanical signal that is subsequently sensed by the osteocytes.About:
This article is published in Bone.The article was published on 2013-06-01. It has received 477 citations till now. The article focuses on the topics: Mechanotransduction & Mechanical load.read more
Citations
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Journal ArticleDOI
The Amazing Osteocyte
TL;DR: Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment.
Journal ArticleDOI
Bone Quality: The Determinants of Bone Strength and Fragility
TL;DR: The complex structure of bone tissue is reviewed and the concept that its mechanical strength stems from the interaction of several different features is highlighted, which emphasizes that while osteoporosis (almost) always causes bone fragility, bone Fragility is not always caused just by osteop orosis, as other important variables also play a major role in this etiology.
Journal ArticleDOI
Biomechanics and Mechanobiology of Trabecular Bone: A Review
Ramin Oftadeh,Ramin Oftadeh,Miguel Perez-Viloria,Juan C. Villa-Camacho,Ashkan Vaziri,Ara Nazarian +5 more
TL;DR: The aims of the current work are to first review the mechanobiology of trabecular bone and then present classical and new approaches for modeling and analyzing the trabECular bone microstructure and macrost structure and corresponding mechanical properties such as elastic properties and strength.
Journal ArticleDOI
Mechanical loading and how it affects bone cells: the role of the osteocyte cytoskeleton in maintaining our skeleton.
TL;DR: This review will focus on the first step in the cascade of events leading to adaptation of bone mass to mechanical loading, i.e., on how osteocytes are able to perceive mechanical stimuli placed on whole bones.
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The clinical utility of bone marker measurements in osteoporosis
Gillian Wheater,Gillian Wheater,Mohsen Elshahaly,Mohsen Elshahaly,SP Tuck,SP Tuck,Harish K. Datta,Jacob M van Laar,Jacob M van Laar +8 more
TL;DR: Improved research is hoped that improved research will lead to optimised markers for the clinical management of osteoporosis and other bone diseases, including a specific marker of bone resorption (CTX) and bone formation (P1NP) in all future studies.
References
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Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.
TL;DR: This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.
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Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
TL;DR: This review compares and contrast PGHS-1 and -2 in the context of the regulation of expression of the two enzymes, the mechanisms of enzyme catalysis, and the biological significance of having two PGHSs.
Journal ArticleDOI
The Amazing Osteocyte
TL;DR: Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment.
Journal ArticleDOI
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
TL;DR: Molecular connections between integrins, cytoskeletal filaments, and nuclear scaffolds may provide a discrete path for mechanical signal transfer through cells as well as a mechanism for producing integrated changes in cell and nuclear structure in response to changes in extracellular matrix adhesivity or mechanics.
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Regulation of bone formation by applied dynamic loads.
Clinton T. Rubin,Lance E. Lanyon +1 more
TL;DR: It appears that functional load-bearing prevents a remodeling process that would otherwise lead to disuse osteoporosis, and a small exposure to, or the first effect of, a suitable dynamic strain regimen appears to be sufficient to prevent the negatively balanced remodeling that is responsible for disuse fractures.