MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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144 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...…or maintenance of the local chromatin landscape to allow access of other factors, since 5hmC is strongly correlated with an open chromatin conformation (Mellén et al., 2012; Mendonca et al., 2014), whereas 5mC is correlated with repressed chromatin (reviewed in Miranda and Jones, 2007)....
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...Possible mechanisms for this action could include modification or maintenance of the local chromatin landscape to allow access of other factors, since 5hmC is strongly correlated with an open chromatin conformation (Mellén et al., 2012; Mendonca et al., 2014), whereas 5mC is correlated with repressed chromatin (reviewed in Miranda and Jones, 2007)....
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141 citations
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...Moreover, the association of 5hmC methyl marks with active chromatin regions [27,36] has challenged the general concept....
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...transcriptionally active chromatin domains [36] and that MeCP2 is an interacting protein partner of TET1 protein [46] , suggesting its role in transcriptional activation....
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...MeCP2 is able to bind to both 5mC and 5hmC [36]....
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...Among the MBPs, MeCP2 has been shown to bind to both 5mC and 5hmC with high affinity and was shown to be a major 5hmC binding protein in the brain [36]....
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139 citations
135 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...5hmC enrichment over the gene body of highly expressed genes has also been noted in mouse ES cells (30), neuronal cells/ tissues (29), and differentiating sperm cells (44) (reviewed in ref....
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...affect chromatin conformation and gene expression by recruiting “reader” proteins that recognize these modifications (29, 49, 50)....
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...1C], reminiscent of its distribution in neurons (29) and in embryonic stem (ES) cells (27, 30)....
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References
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
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12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
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5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
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4,503 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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