MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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87 citations
86 citations
Cites methods from "MeCP2 binds to 5hmc enriched within..."
...R133P ND ND DNA interface ND Not made R133L ND Reduced [62,142,186] DNA interface ND Not made S134C Reduced [90] Binding [62,142] DNA interface Destabilised [89,90] Not made S134F Reduced [58] ND DNA interface (Backbone) ND Not made S134P ND ND DNA interface (Backbone) ND Not made K135E ND Reduced [62] DNA interface (Backbone) ND Not made L138S ND ND Alpha helix ND Not made P152R Reduced [90] Binding [62,142,186] Loop Destabilised [89,90] Not made F155S Reduced [90,187,188] Reduced [62,186,190] Loop Destabilised [194] Not made D156E Reduced [90] Reduced [62] Asx-ST motif Destabilised [89,90] Not made D156A ND ND Asx-ST motif ND Not made F157L ND ND Asx-ST motif ND Not made F157I ND ND Asx-ST motif ND Not made T158M Reduced [83,90,187,188] Reduced [15,62,65,87,93,142,190] Asx-ST motif Destabilised [15,60,87,93,194] RTT-like [15,87,93]...
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86 citations
86 citations
References
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
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12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
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5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
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4,503 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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