MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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44 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Moreover, gene body 5mC and gene expression are inversely correlated (Mellen et al., 2012)....
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44 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...This modification is especially enriched in multi-exonic, highly expressed brain genes [33]....
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44 citations
44 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...MeCP2 is enriched in brain and binds to methylated cytosine and hydroxymethylcytosine (Mellen et al., 2013), so the alteration of MeCP2 expression indicated the interruption of DNA methylation and demethylation processes....
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References
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
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12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
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5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
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4,503 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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