MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
Citations
38 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...The 5hmC mark has been studied in several cell types, such as mouse embryonic stem cells (mESCs) [2,3], neuronal cells [4-6] and adipocytes [7]....
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38 citations
38 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Advances in cell sorting methods, as well as DNA collection from multiple tissue sources will allow us to gain a more comprehensive overview of CM-dependent epigenetic memory [58], at the “body-wide” level....
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...Developmental timing [57] and cell-specificity [58] of CM-induced DNA methylation adaptations remain also largely unknown....
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37 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Studies have correlated 5hmC presence in gene bodies with increased gene expression [44, 47], alternative splicing [21], and with a depletion of 5mC at the same site [48]....
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37 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Among the tissues and cells investigated for this relationship, where 5hmC has been associated with increased expression, are brain (7, 42), chondrocytes (13), and mouse embryonic stem cells (14, 37, 43)....
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References
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
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12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
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5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
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4,503 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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