MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
Citations
17 citations
17 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...TADs are regions of the genome where DNA sequences physically contact each other more frequently than regions outside of that TAD (Hansen et al., 2018; Merkenschlager and Nora, 2016; Ruiz-Velasco and Zaugg, 2017)....
[...]
17 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Several specific molecular readers of 5hmC have been identified, including transcriptional regulators, chromatin modifiers and DNA damage and repair proteins[8-12]....
[...]
16 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Another 5hmC reader, MeCP2, binds 5hmC but is not required for maintaining 5hmC levels.(36) Therefore, the biologic significance of the binding between UHRF2 and 5hmC remains to be established....
[...]
16 citations
References
13,356 citations
12,293 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
[...]
12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
[...]
5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
[...]
4,503 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
[...]