MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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Cites background from "MeCP2 binds to 5hmc enriched within..."
...assemble the repressor complexes to suppress transcription of linked genes.(48,49) While MeCP2 can also act as an activator in specific neuronal cells,(49,50) it acts as a repressor in binding to...
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16 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...These proteins use the same 5mCbinding domain to interact with 5hmC, but the 5hmC binding affinity was similar to or weaker than their 5mC binding affinities (18, 19)....
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...Previous studies have shown that some 5mC readers, such as UHRF1 and MeCP2, can also bind 5hmC (18, 19)....
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
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12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
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5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
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"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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