MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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9 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Supporting a role for activation, genome-wide studies indicate that MeCP2 binds to 5hmC which is enriched in active genes during neuronal differentiation [13] and in terminally differentiated neurons [18,29]....
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9 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...However, the observation that more than half of MeCP2 molecules in the brain reside in low-condensed chromatin regions which have lower 5mC levels, and the recent insights about multifaceted DNA-binding properties of MeCP2 (Mellén et al. 2012; Baker et al. 2013) suggest that MeCP2 function might be more complex (Guy et al....
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...…than half of MeCP2 molecules in the brain reside in low-condensed chromatin regions which have lower 5mC levels, and the recent insights about multifaceted DNA-binding properties of MeCP2 (Mellén et al. 2012; Baker et al. 2013) suggest that MeCP2 function might be more complex (Guy et al. 2011)....
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References
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
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12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
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5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
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"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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