MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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8 citations
Cites background or result from "MeCP2 binds to 5hmc enriched within..."
...This confirms recent results obtained by other groups that used different mapping technologies to investigate mouse neuronal cell types [8,9]....
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...And is there additional epigenetic heterogeneity between neuron subtypes? We can now expect new answers from the study of mouse genetic models, as well as from the identification of proteins that bind to methylated and hydroxy methylated cytosine residues [9]....
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8 citations
8 citations
Cites background from "MeCP2 binds to 5hmc enriched within..."
...Studies have shown that 5hmC is an epigenetic mark present in the mammalian brain [134], that 5hmC is dynamically regulated in development [135], and that cell type-specific patterns of 5hmC in the genome are present in active genes [136]....
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References
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Transcript abundance was measured in fragments per kilobase of exon per million fragments mapped (FPKM) similarly to RPKM used in (Mortazavi et al., 2008)....
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12,142 citations
"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...Finally, differentially expressed genes were identified by performing a negative binomial test using the DESeq package (Anders and Huber, 2010) of R/Bioconductor (Gentleman et al., 2004)....
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5,155 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...This is expected because hydroxylation of 5mC results in 5hmC (Tahiliani et al., 2009), and both of these marks cannot exist on one base....
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4,503 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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