MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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...hmC accumulates during early postnatal brain development in mice (31, 32), becoming enriched in highly expressed genes (33)....
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...Overall, transcriptional activity is associated with intragenic hmCG enrichment, as reported (33), with in utero establishment of adult hmCG patterns for cell type–specific genes and loss of hmC enrichment associated with developmentally coupled transcriptional down-regulation....
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...These constitutively highly expressed genes enriched for neuronal function also show extensive intragenic mCH hypomethylation in neurons in contrast to glia (box 3), and they are enriched for hmCG (box 4) as previously described (32, 33)....
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...Our base-resolution analysis of hmC using TAB-Seq revealed that intragenic and global hmCG levels are largely equivalent between chromosomes, whereas hmCG/CG is 22% lower on the male ChrX, consistent with previous reports from enrichment based detection of hmC (32, 33) (Fig....
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Cites background from "MeCP2 binds to 5hmc enriched within..."
...…binding of Uhrf2 to hmC, suggesting specific biological roles for mC and hmC. Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation....
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References
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"MeCP2 binds to 5hmc enriched within..." refers methods in this paper
...To confirm this result, similar affinity purifications were repeated from brain nuclear extracts of wild-type (WT) and Mecp2 knockout (KO) animals using beads coated with DNA containing C or 5hmC, and assayed using Southwestern analysis (Campoy et al., 1995)....
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13 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
..., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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...…been shown to occur in response to a variety 1424 Cell 151, 1417–1430, December 21, 2012 ª2012 Elsevier Inc. of stimuli (Chen et al., 2003; Tao and Wu, 2009; Rutlin and Nelson, 2011; Adkins and Georgel, 2011; Gonzales et al., 2012) could alter its substrate specificity and downstream functions....
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...…each cell type, the phenotypic consequences of changes in the function of MeCP2, whether as a result of mutation (Adkins and Georgel, 2011; Tao andWu, 2009; Amir et al., 1999) or posttranslational modification (Rutlin and Nelson, 2011; Gonzales et al., 2012), will be cell type and circuit specific....
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...of stimuli (Chen et al., 2003; Tao and Wu, 2009; Rutlin and Nelson, 2011; Adkins and Georgel, 2011; Gonzales et al., 2012) could alter its substrate specificity and downstream functions....
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10 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…that have been shown to occur in response to a variety 1424 Cell 151, 1417–1430, December 21, 2012 ª2012 Elsevier Inc. of stimuli (Chen et al., 2003; Tao and Wu, 2009; Rutlin and Nelson, 2011; Adkins and Georgel, 2011; Gonzales et al., 2012) could alter its substrate specificity and downstream…...
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...of stimuli (Chen et al., 2003; Tao and Wu, 2009; Rutlin and Nelson, 2011; Adkins and Georgel, 2011; Gonzales et al., 2012) could alter its substrate specificity and downstream functions....
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