MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
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...hmC accumulates during early postnatal brain development in mice (31, 32), becoming enriched in highly expressed genes (33)....
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...Overall, transcriptional activity is associated with intragenic hmCG enrichment, as reported (33), with in utero establishment of adult hmCG patterns for cell type–specific genes and loss of hmC enrichment associated with developmentally coupled transcriptional down-regulation....
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...These constitutively highly expressed genes enriched for neuronal function also show extensive intragenic mCH hypomethylation in neurons in contrast to glia (box 3), and they are enriched for hmCG (box 4) as previously described (32, 33)....
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...Our base-resolution analysis of hmC using TAB-Seq revealed that intragenic and global hmCG levels are largely equivalent between chromosomes, whereas hmCG/CG is 22% lower on the male ChrX, consistent with previous reports from enrichment based detection of hmC (32, 33) (Fig....
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...…binding of Uhrf2 to hmC, suggesting specific biological roles for mC and hmC. Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation....
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References
178 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...They are also consistent with the observations that MeCP2 stably associates with nucleosomes (Chandler et al., 1999), that it can compete with histone H1 for nucleosomebinding sites (Ghosh et al., 2010), and that the levels of MeCP2 and histone H1 are inversely correlated in neurons (Skene et al.,…...
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...They are also consistent with the observations that MeCP2 stably associates with nucleosomes (Chandler et al., 1999), that it can compete with histone H1 for nucleosomebinding sites (Ghosh et al....
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145 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...GCs are the smallest and most numerous neurons of the cerebellum, present at several hundred times the abundance of PCs (Palay and Chan-Palay, 1974; Lange, 1975)....
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137 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...time to the presence ofmuchmore stable complexes established within that domain by binding of MeCP2 or other less abundant MBD family proteins to 5mC (Lopez-Serra et al., 2006)....
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...See also Figure S7. time to the presence ofmuchmore stable complexes established within that domain by binding of MeCP2 or other less abundant MBD family proteins to 5mC (Lopez-Serra et al., 2006)....
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129 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...…also consistent with the observations that MeCP2 stably associates with nucleosomes (Chandler et al., 1999), that it can compete with histone H1 for nucleosomebinding sites (Ghosh et al., 2010), and that the levels of MeCP2 and histone H1 are inversely correlated in neurons (Skene et al., 2010)....
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..., 1999), that it can compete with histone H1 for nucleosomebinding sites (Ghosh et al., 2010), and that the levels of MeCP2 and histone H1 are inversely correlated in neurons (Skene et al....
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91 citations
"MeCP2 binds to 5hmc enriched within..." refers background in this paper
...To determine if this is the case, binding of MeCP2 MBDs (amino acids [aa] 1–205) carrying a variety of previously characterized RTT mutations were assayed (Kudo et al., 2003)....
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