Journal ArticleDOI
Mediation of the antilipolytic and lipogenic effects of insulin in adipocytes by intracellular accumulation of hydrogen peroxide.
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TLDR
Endogenous H 2 O 2 appears to satisfy the manifold criteria for a ‘second messenger’ of insulin, and increasing availability of d -glucose may counterbalance these effects by replenishing the reducing equivalents.About:
This article is published in Biochemical Pharmacology.The article was published on 1980-05-01. It has received 34 citations till now. The article focuses on the topics: Insulin & Pentose phosphate pathway.read more
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Journal ArticleDOI
A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation.
Anne Nègre-Salvayre,Christophe Hirtz,Georges Carrera,Rémy Cazenave,Muriel Troly,Robert Salvayre,Luc Pénicaud,Louis Casteilla +7 more
TL;DR: Results strongly suggest that UCP2 is sensitive to GDP and that the UCPs, particularly U CP2, are able to modulate H2O2 mitochondrial generation, which supports a role for UCP1 in cellular (patho‐) physiological processes involving free radicals generated by mitochondria, such as oxidative damage, inflammation, or apoptosis.
Journal ArticleDOI
Hydrogen peroxide is involved in hamster sperm capacitation in vitro.
TL;DR: Results suggest that H2O2 produced by hamster sperm plays a significant role during capacitation, possibly in membrane reorganization to facilitate the fusion that takes place during exocytosis of the acrosomal contents.
Book ChapterDOI
Does vanadium play a role in cellular regulation
TL;DR: This chapter highlights physiological and metabolic effects on enzyme activities of vanadium, affecting the transition state of phosphate, which seems to have an affinity for the binding sites on these enzymes.
Journal ArticleDOI
The mechanism of the insulin-like effects of ionic zinc.
J M May,C S Contoreggi +1 more
TL;DR: The insulin-like effects of ionic zinc (Zn2+) in adipocytes are caused not only by direct effects of the ion on intracellular metabolism but also by indirect effects related to H2O2 generation.
Journal ArticleDOI
Generation of H2O2 in biomembranes
TL;DR: Under aerobic conditions generation of H202 by a Variety of biomembranes has now been found to be a physiological event interlinked with phenomena such as phagocytosis, transport processes and thermogenesis in some as yet unidentified way.
References
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Journal ArticleDOI
Metabolism of isolated fat cells. i. effects of hormones on glucose metabolism and lipolysis.
The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis
TL;DR: This article marks the beginning of Rodbell's interest in cell receptors and related his discovery that fat cells could be isolated from other cells by treating them with preparations of collagenase, and also found that insulin could stimulate glucose uptake.
Journal ArticleDOI
A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.
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