Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
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...Phase separation has also been recently implicated in driving gene activation through nanoscale transcriptional condensates assembled at enhancer-rich gene clusters (Cho et al., 2018; Chong et al., 2018; Sabari et al., 2018)....
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...…in which transcriptionally active condensates such as the nucleolus (Berry et al., 2015; Feric et al., 2016) and super-enhancer clusters (Cho et al., 2018; Sabari et al., 2018) play bifunctional roles, serving to both filter out non-specific elements of the genome, while pulling…...
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...…has also been recently implicated in driving gene activation through nanoscale transcriptional condensates assembled at enhancer-rich gene clusters (Cho et al., 2018; Chong et al., 2018; Sabari et al., 2018). ell 175, 1481–1491, November 29, 2018 ª 2018 Elsevier Inc. 1481 Despite the growing…...
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..., 2016) and super-enhancer clusters (Cho et al., 2018; Sabari et al., 2018) play bifunctional roles, serving to both filter out non-specific elements of the genome, while pulling together targeted regions to which they are bound (Figure 7)....
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