Journal ArticleDOI
Medical aspects of drug use in the gym
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This work considers medical aspects of performance-enhancing drugs, and clinicians in many settings may see patients who are experiencing problems related to such (usually covert) use.Abstract:
Use of performance-enhancing drugs by athletes and bodybuilders appears to be common in the UK.1–3 Although there are no comprehensive national figures, there is evidence that such drugs are also widely used in sections of the general and gym-using populations, in the expectation of physical and cosmetic benefits.1,4 Use of performance-enhancing drugs often takes place with little knowledge or acceptance of potential harmful effects, and clinicians in many settings may see patients who are experiencing problems related to such (usually covert) use. Here we consider medical aspects of performance-enhancing drugs.read more
Citations
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Pharmacology of anabolic steroids
TL;DR: Anabolic steroids are being considered for the treatment of cachexia associated with chronic disease states, and to address loss of muscle mass in the elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life.
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Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.
Michael L. Mohler,Casey E. Bohl,Amanda Jones,Christopher C. Coss,Ramesh Narayanan,Yali He,Dong Jin Hwang,James T. Dalton,Miller Duane D +8 more
TL;DR: This Award Address attempts to chronicle the landmark discoveries, organize the SARM landscape into clinically relevant bins, and provide insight into the clinical prospects for SARMs.
Journal ArticleDOI
Abuse of supraphysiologic doses of anabolic steroids.
Ryan C.W. Hall,Richard C.W. Hall +1 more
TL;DR: The article concludes by looking at the major detrimental side effects, such as liver damage and cardiovascular changes, which physicians may encounter when treating AAS abusers.
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Steroid and prescription medicine abuse in the health and fitness community: A regional study.
TL;DR: The present study indicated that the most used medicine/drug from less than reputable sources was still AAS but that, as a consequence of the internet revolution, they were being caught up by the more expensive designer drugs, particularly growth hormone.
Journal ArticleDOI
Psychotropic drugs and the perioperative period: a proposal for a guideline in elective surgery.
TL;DR: Both the physical and psychiatric risks of patients who use antipsychotics and other antidepressants should be regarded as enhanced and patients on SSRIs with higher physical or psychiatric risks should be seen in consultation.
References
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Journal ArticleDOI
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
Shalender Bhasin,Thomas W. Storer,Nancy Berman,Carlos Callegari,Brenda Clevenger,Jeff M. Phillips,Thomas J. Bunnell,Ray Tricker,Aida Shirazi,Richard Casaburi +9 more
TL;DR: Those given testosterone had greater increases than those given placebo in muscle size in their arms and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively.
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Psychiatric and Medical Effects of Anabolic-Androgenic Steroid Use: A Controlled Study of 160 Athletes
Harrison G. Pope,David L. Katz +1 more
TL;DR: Major mood disturbances associated with anabolic-androgenic steroids may represent an important public health problem for athletes using steroids and sometimes for the victims of their irritability and aggression.
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Effects of Supraphysiologic Doses of Testosterone on Mood and Aggression in Normal Men: A Randomized Controlled Trial
TL;DR: In a randomized, placebo-controlled, crossover trial, 50 participants who received 600 mg/wk of testosterone cypionate, 42 (84%) exhibited minimal psychiatric effects (maximum YMRS score, 20), while the other participants did not differ significantly on baseline demographic, psychological, laboratory or physiological measures.
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Neuropsychiatric Effects of Anabolic Steroids in Male Normal Volunteers
Tung Ping Su,Michael Pagliaro,Peter Schmidt,David Pickar,Owen M. Wolkowitz,Owen M. Wolkowitz,David R. Rubinow +6 more
TL;DR: This is the first placebo-controlled prospective study demonstrating the adverse and activating mood and behavioral effects of anabolic steroids.
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Effect of growth hormone and resistance exercise on muscle growth in young men
Kevin E. Yarasheski,J. A. Campbell,Kenneth Smith,Michael J. Rennie,John O. Holloszy,Dennis M. Bier +5 more
TL;DR: In the young men studied, resistance exercise with or without GH resulted in similar increments in muscle size, strength, and muscle protein synthesis, indicating that the larger increase in FFM with GH treatment was probably due to an increase in lean tissue other than skeletal muscle and resistance training supplemented with GH did not further enhance muscle anabolism and function.