Melon and banana sensitivity coincident with ragweed pollinosis
TL;DR: Passive cutaneous anaphylaxis in guinea pigs demonstrated a strong cross-reaction between ragweed antigen and cantaloupe antibody, suggesting common antigenic determinants as an explanation for the melon sensitivity-ragweed pollinosis syndrome.
About: This article is published in Journal of Allergy.The article was published on 1970-05-01. It has received 179 citations till now. The article focuses on the topics: Ragweed & Melon.
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TL;DR: A limited number of foods are responsible for the vast majority of food-induced allergic reactions: milk, egg, peanuts, fish, and tree nuts in children and peanuts, tree nuts, fish and shellfish in adults.
Abstract: Up to 8% of children less than 3 years of age and approximately 2% of the adult population experience food-induced allergic disorders. A limited number of foods are responsible for the vast majority of food-induced allergic reactions: milk, egg, peanuts, fish, and tree nuts in children and peanuts, tree nuts, fish, and shellfish in adults. Food-induced allergic reactions are responsible for a variety of symptoms involving the skin, gastrointestinal tract, and respiratory tract and may be caused by IgE-mediated and non-IgE-mediated mechanisms. In part 1 of this series, immunopathogenic mechanisms and clinical disorders of food allergy are described.
838 citations
TL;DR: The causes and management of food intolerance are discussed in an edited account of a recent report from the National Dairy Council (1998).
541 citations
TL;DR: Approaches to introduce such proteins as a measure to protect plants against diseases should be performed with caution as they may increase the allergenicity of these crops.
Abstract: Pollen-allergic patients frequently present allergic symptoms after ingestion of several kinds of plant-derived foods. The majority of these reactions is caused by four distinct cross-reactive structures that are present in birch pollen. Proteins that share common epitopes with Bet v 1, the major birch pollen allergen, occur in pollens of several tree species: apples, stone fruits, celery, carrot, nuts, and soybeans. Approximately 70% of our patients who are allergic to birch pollen may experience symptoms after consumption of foods from these groups. In contrast, two minor allergenic structures-profilins and cross-reactive carbohydrate determinants (CCD)-that sensitize approximately 10-20% of all pollen-allergic patients are also present in grass pollen and weed pollen. Moreover, IgE-binding proteins related to the birch pollen minor allergen Bet v 6 have been found in many vegetable foods such as apple, peach, orange, lychee fruit, strawberry, persimmon, zucchini, and carrot. Frequently, the occurrence of cross-reactive IgE antibodies is not correlated with the development of clinical food allergy. In particular, the clinical relevance of sensitization to CCD is doubtful. Generally, pollen-related allergens tend to be more labile during heating procedures and in the digestive tract compared to allergens from classical allergenic foods such as peanut. However, recent DBPCFC studies have shown that both cooked celery and roasted hazelnuts still pose an allergenic risk for pollen-sensitized subjects. Since pathogenesis-related proteins share several common features with allergens and both the Bet v 1 and the Bet v 6-related food allergens are defense-related proteins, approaches to introduce such proteins as a measure to protect plants against diseases should be performed with caution as they may increase the allergenicity of these crops.
458 citations
TL;DR: Current management of food allergy focuses on accurate diagnosis, appropriate counseling regarding strict allergen avoidance with review of available educational resources, emergency preparedness, instruction on the use of self-injectable epinephrine, and ongoing surveillance for the possible development of tolerance.
Abstract: Purpose of review The present review serves to address food allergy, which is a common problem encountered by the general pediatrician. Between 4 and 6% of US children have an allergic reaction to at least one food, and the prevalence of some food allergies appears to be increasing. Recent findings A combination of genetic influences, characteristics of food antigen processing, and timing of food introduction may influence the development of food allergy. Avoidance of highly allergenic foods beyond 4-6 months may not be effective at preventing the development of food allergy in most children, and the effect of specific early introduction of allergenic foods is being investigated. Oral immunotherapy is under investigation but may be limited in future use by several factors, including a significant rate of allergic reactions. Summary Current management of food allergy focuses on accurate diagnosis, appropriate counseling regarding strict allergen avoidance with review of available educational resources, emergency preparedness, instruction on the use of self-injectable epinephrine, and ongoing surveillance for the possible development of tolerance.
412 citations
TL;DR: Skin sensitivity to apple, carrot and potato, clinically related to birch pollinosis was investigated and children who noticed clinical symptoms when eating apple, raw carrot or potato were found to have a significantly larger SPT reaction than children with a negative history.
Abstract: Skin sensitivity to apple, carrot and potato, clinically related to birch pollinosis was investigated. Different skin test techniques using fresh fruit were compared. A simple prick test (SPT) technique with a lancet piercing the apple peel just before pricking the skin was shown to be the most practical and to give reproducible results. The allergenic activity in apple was found to be heat labile and deteriorated during storage at room temperature. Apple, carrot, potato, hazelnut and birch reactivity was transferable in Prausnitz-Kustner test like IgE antibodies. SPT reactivity to fresh material from apple, carrot and potato was investigated in 174 children of whom 128 suffered from pollen allergy. Positive SPT results were obtained almost exclusively in children who were SPT positive to a birch pollen extract. Children who noticed clinical symptoms when eating apple, raw carrot or potato were found to have a significantly larger SPT reaction than children with a negative history.
403 citations
Cites background from "Melon and banana sensitivity coinci..."
...A similar association has been reported between ragweed pollinosis and clinical sensitivity to melon and banana (3)....
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383 citations
TL;DR: Findings suggest that the priming effect is related to a local change in the challenged tissue rather than a systemic change, and that priming is nonspecific.
269 citations
TL;DR: It was shown that environmental exposure during the ragweed pollinating season also primed ragweed-sensitive individuals, and the priming effect was readily reversed by stopping challenges for several days.
200 citations
TL;DR: This has the purpose of warning against the possible misdiagnosis of malignant carcinoid tumours by analysis of urine for elevated 5-hydroxyindoleacetic acid-levels when these are spuriously high following a diet rich in serotonin or its precursors.
Abstract: SEVERAL investigators have noted and studied the presence of serotonin and its precursors in fruit, mainly banana and tomato1–4. As well as aiding the study of serotonin itself, this has the purpose of warning against the possible misdiagnosis of malignant carcinoid tumours by analysis of urine for elevated 5-hydroxyindoleacetic acid-levels when these are spuriously high following a diet rich in serotonin or its precursors.
50 citations