Journal ArticleDOI
Membrane potential correlates of sensory perception in mouse barrel cortex
Shankar Sachidhanandam,Varun Sreenivasan,Alexandros Kyriakatos,Yves Kremer,Carl C.H. Petersen +4 more
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TLDR
The data reveal dynamic processing in the sensory cortex during task performance, with an early sensory response reliably encoding the stimulus and later secondary activity contributing to driving the subjective percept.Abstract:
Neocortical activity can evoke sensory percepts, but the cellular mechanisms remain poorly understood. We trained mice to detect single brief whisker stimuli and report perceived stimuli by licking to obtain a reward. Pharmacological inactivation and optogenetic stimulation demonstrated a causal role for the primary somatosensory barrel cortex. Whole-cell recordings from barrel cortex neurons revealed membrane potential correlates of sensory perception. Sensory responses depended strongly on prestimulus cortical state, but both slow-wave and desynchronized cortical states were compatible with task performance. Whisker deflection evoked an early (<50 ms) reliable sensory response that was encoded through cell-specific reversal potentials. A secondary late (50-400 ms) depolarization was enhanced on hit trials compared to misses. Optogenetic inactivation revealed a causal role for late excitation. Our data reveal dynamic processing in the sensory cortex during task performance, with an early sensory response reliably encoding the stimulus and later secondary activity contributing to driving the subjective percept.read more
Citations
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Neural correlates of consciousness: progress and problems
TL;DR: Recent findings showing that the anatomical neural correlates of consciousness are primarily localized to a posterior cortical hot zone that includes sensory areas, rather than to a fronto-parietal network involved in task monitoring and reporting are described.
Journal ArticleDOI
Waking State: Rapid Variations Modulate Neural and Behavioral Responses.
Matthew J. McGinley,Martin Vinck,Jacob Reimer,Renata Batista-Brito,Edward Zagha,Cathryn R. Cadwell,Andreas S. Tolias,Jessica A. Cardin,David A. McCormick +8 more
TL;DR: By taking fluctuations in state into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought.
Journal ArticleDOI
Distributed coding of choice, action and engagement across the mouse brain
TL;DR: Recordings from 30,000 neurons in 42 brain regions are used to delineate the spatial distribution of neuronal activity underlying vision, choice, action and behavioural engagement in mice and reveal organizing principles for the distribution of neurons encoding behaviourally relevant variables across the mouse brain.
Journal ArticleDOI
Conscious Processing and the Global Neuronal Workspace Hypothesis.
George A. Mashour,Pieter R. Roelfsema,Pieter R. Roelfsema,Jean-Pierre Changeux,Jean-Pierre Changeux,Jean-Pierre Changeux,Stanislas Dehaene,Stanislas Dehaene +7 more
TL;DR: The GNW hypothesis proposes that, in the conscious state, a non-linear network ignition associated with recurrent processing amplifies and sustains a neural representation, allowing the corresponding information to be globally accessed by local processors.
Journal ArticleDOI
Prefrontal Parvalbumin Neurons in Control of Attention
TL;DR: Fast-spiking parvalbumin (FS-PV) interneurons in medial prefrontal cortex (mPFC) uniformly show increased and sustained firing during goal-driven attentional processing, correlating to the level of attention.
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