Memory, navigation and theta rhythm in the hippocampal-entorhinal system
György Buzsáki,Edvard I. Moser +1 more
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TLDR
It is proposed that mechanisms of memory and planning have evolved from mechanisms of navigation in the physical world and hypothesize that the neuronal algorithms underlying navigation in real and mental space are fundamentally the same.Citations
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Functional organization of the hippocampal longitudinal axis
TL;DR: Together, anatomical studies and electrophysiological recordings in rodents suggest a model in which functional long-axis gradients are superimposed on discrete functional domains, which provides a potential framework to explain and test the multiple functions ascribed to the hippocampus.
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Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
TL;DR: Alteration of the physiological mechanisms supporting SPW‐Rs leads to their pathological conversion, “p‐ripples,” which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease.
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Long-axis specialization of the human hippocampus
TL;DR: It is suggested that various long-axis specializations arise out of differences between the anterior and posterior hippocampus in large-scale network connectivity, the organization of entorhinal grid cells, and subfield compositions that bias the aHPC and pHPC towards pattern completion and separation, respectively.
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The Molecular and Systems Biology of Memory
TL;DR: In this Review, the molecular, cellular, and circuit mechanisms that underlie how memories are made, stored, retrieved, and lost are examined.
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Creating a False Memory in the Hippocampus
Steve Ramirez,Xu Liu,Xu Liu,Pei-Ann Lin,Junghyup Suh,Michele Pignatelli,Roger L. Redondo,Roger L. Redondo,Tomás J. Ryan,Tomás J. Ryan,Susumu Tonegawa,Susumu Tonegawa +11 more
TL;DR: The data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means through reactivation of memory engram–bearing cells in the hippocampus.
References
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Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
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Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
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Neuronal Oscillations in Cortical Networks
György Buzsáki,Andreas Draguhn +1 more
TL;DR: Recent findings indicate that network oscillations bias input selection, temporally link neurons into assemblies, and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation and long-term consolidation of information.
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Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.
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Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory.
TL;DR: The account presented here suggests that memories are first stored via synaptic changes in the hippocampal system, that these changes support reinstatement of recent memories in the neocortex, that neocortical synapses change a little on each reinstatement, and that remote memory is based on accumulated neocorticals changes.