Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications.
Hao Li,Pinxue Li,Zhen Yang,Cangjian Gao,Liwei Fu,Zhiyao Liao,Tianyuan Zhao,Fuyang Cao,Wei Chen,Yu Peng,Zhiguo Yuan,Xiang Sui,Shuyun Liu,Quanyi Guo +13 more
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TLDR
In this paper, a review of the current polymers used to fabricate meniscal scaffolds and their applications in vivo and in vitro to evaluate their potential utility in meniscal tissue engineering is presented.Abstract:
Knee menisci are structurally complex components that preserve appropriate biomechanics of the knee. Meniscal tissue is susceptible to injury and cannot heal spontaneously from most pathologies, especially considering the limited regenerative capacity of the inner avascular region. Conventional clinical treatments span from conservative therapy to meniscus implantation, all with limitations. There have been advances in meniscal tissue engineering and regenerative medicine in terms of potential combinations of polymeric biomaterials, endogenous cells and stimuli, resulting in innovative strategies. Recently, polymeric scaffolds have provided researchers with a powerful instrument to rationally support the requirements for meniscal tissue regeneration, ranging from an ideal architecture to biocompatibility and bioactivity. However, multiple challenges involving the anisotropic structure, sophisticated regenerative process, and challenging healing environment of the meniscus still create barriers to clinical application. Advances in scaffold manufacturing technology, temporal regulation of molecular signaling and investigation of host immunoresponses to scaffolds in tissue engineering provide alternative strategies, and studies have shed light on this field. Accordingly, this review aims to summarize the current polymers used to fabricate meniscal scaffolds and their applications in vivo and in vitro to evaluate their potential utility in meniscal tissue engineering. Recent progress on combinations of two or more types of polymers is described, with a focus on advanced strategies associated with technologies and immune compatibility and tunability. Finally, we discuss the current challenges and future prospects for regenerating injured meniscal tissues.read more
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Hydrogel composite scaffolds achieve recruitment and chondrogenesis in cartilage tissue engineering applications
Bo Huang,Pinxue Li,Mingxue Chen,Liqing Peng,Xujiang Luo,Guangzhao Tian,Lei Wu,Qinyu Tian,Huo Li,Yu Yang,Shuangpeng Jiang,Zhen Yang,Kangkang Zha,Xiang Sui,Shuyun Liu,Quanyi Guo +15 more
TL;DR: Wang et al. as discussed by the authors constructed a skeleton-based scaffold that can be easily molded to fill cartilage defects of any shape that fit tightly into the host cartilage, and the skeleton provided a three-dimensional microenvironment supporting cell adhesion, proliferation and chondrogenic differentiation.
Journal ArticleDOI
Recent advance of CuO-CeO2 catalysts for catalytic elimination of CO and NO
TL;DR: In this article, the reaction mechanism of CuO-CeO2 catalysts in CO catalytic oxidation and NO catalytic reduction by CO and the key influencing factors of activity, such as Cu:Ce ratio, synthetic methods, calcination temperature, CeO2 shape, O2 content, etc., the influence of the above factors on the surface active sites of CUO-ceO 2 catalyst, surface oxygen vacancies, the interaction between Cu and Ce redox pairs, and the specific surface area of the catalyst are briefly described.
Journal ArticleDOI
Meniscus regeneration by 3D printing technologies: Current advances and future perspectives
Elena Stocco,Andrea Porzionato,Enrico De Rose,Silvia Barbon,Raffaele De Caro,Veronica Macchi +5 more
TL;DR: This literature review provides a state-of-the-art on 3D printing for meniscus reconstruction and demonstrates how the integration of different expertise is required to successfully address native tissues complexities.
Journal ArticleDOI
Integrated bioactive scaffold with aptamer‐targeted stem cell recruitment and growth factor‐induced pro‐differentiation effects for anisotropic meniscal regeneration
Li Hao,Zhao Tianyuan,Cao Fuyang,Deng Haoyuan,He Songlin,Li Jianwei,Liu Shu-yun,Yang Zhen,Yuan Zhiguo,Guo Quanyi +9 more
TL;DR: In this paper , a fiber-reinforced porous scaffold was developed based on aptamer Apt19S-mediated mesenchymal stem cell (MSC)-specific recruitment and dual growth factor (GF)-enhanced meniscal differentiation.
Journal ArticleDOI
Integrated bioactive scaffold with aptamer‐targeted stem cell recruitment and growth factor‐induced pro‐differentiation effects for anisotropic meniscal regeneration
Hao Li,Tianyuan Zhao,Fuyang Cao,Haoyuan Deng,Songlin He,Jianwei Li,Shuyun Liu,Zhen Yang,Zhiguo Yuan,Quanyi Guo +9 more
TL;DR: The in vivo results demonstrated that the sequential release system of Apt/GF‐scaffolds increased neomeniscal formation in rabbit critical‐sized meniscectomies, and the novel delivery system shows potential for guiding meniscal regeneration in situ.
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