Meprins, membrane-bound and secreted astacin metalloproteinases.
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341 citations
Cites background from "Meprins, membrane-bound and secrete..."
...Meprin b is made as an inactive proenzyme and requires proteolytic cleavage for activation (Sterchi et al., 2008)....
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225 citations
Cites background from "Meprins, membrane-bound and secrete..."
...In humans, there are six astacin genes, including two meprins, three bone morphogenetic protein1 (BMP1)/Tolloid like (TLD) proteases and one ovastacin (Sterchi et al., 2008) (Table 1)....
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...Astacins family includes several hundred protein detected in species ranging from hydra to humans (for a review see Ge and Greenspan, 2006; Hopkins et al., 2007; Sterchi et al., 2008)....
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...Meprin subunits a and b cleave a variety of biologically active peptides; in particular, we want to point out gastrin and cholecystokin on one side (which are substrates for meprin b) and substance P and many cytokines on the other side (which are substrates for meprin a, see Sterchi et al., 2008)....
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"Meprins, membrane-bound and secrete..." refers background in this paper
...…M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript G1 domain and in the linker between the G1 and G2 domains, and fibronectin is cut within the proteolytically vulnerable linker regions between fibronectin type III repeats 1 and 2, 3 and 4, and 5 and 6 (Pankov and Yamada 2002)....
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