Mesenchymal stem cells as trophic mediators.
Citations
3,390 citations
Cites background from "Mesenchymal stem cells as trophic m..."
...Stem cell therapies have already proved successful at restoring cardiac function in injured hearts [173], therefore they might prove successful for a wide variety of fibroproliferative disorders....
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1,855 citations
1,816 citations
Cites background from "Mesenchymal stem cells as trophic m..."
...In support of this paracrine hypothesis, many studies have observed that MSCs secrete cytokines, chemokines, and growth factors that could potentially repair injured cardiac tissue mainly through cardiac and vascular tissue growth and regeneration (Caplan and Dennis, 2006b; Liu and Hwang, 2005)....
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...These proteins generally included cytokines, chemokines, and other growth factors (Caplan and Dennis, 2006a)....
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...Recent reports have suggested that some of these reparative effects are mediated by paracrine factors secreted by MSCs (Caplan and Dennis, 2006a; Gnecchi et al., 2005, 2006; Schafer and Northoff, 2008)....
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...The trophic effects of MSC transplantation on ameliorating the deleterious consequences of myocardial ischemia have been implicated in several studies (Caplan and Dennis, 2006a)....
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1,473 citations
Cites background from "Mesenchymal stem cells as trophic m..."
...That is, if one function is to nurture HSCs and their progeny, then it is possible that nonhematopoietic cells may also benefit from a ‘‘nursing’’ effect conveyed by direct interaction with BMSCs and/or by paracrine stimuli (Caplan and Dennis, 2006)....
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1,402 citations
Cites background from "Mesenchymal stem cells as trophic m..."
...Indeed, all of these disorders and conditions appear to be muted or cured by the injected or infused MSCs based on two generalizable therapeutic activities (Caplan and Dennis, 2006): immunomodulation and trophic activities (Figure 2)....
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References
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5,331 citations
"Mesenchymal stem cells as trophic m..." refers background in this paper
...Whether HSCs differentiate into cardiac cells is a subject of debate [Orlic et al., 2001; Balsam et al., 2004; Kawada et al., 2004; Murry et al., 2004]; for an extensive review on this debate and on cardiac repair in general, see Laflamme and Murry [2005]....
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4,861 citations
"Mesenchymal stem cells as trophic m..." refers background in this paper
...One class of multipotent adult progenitors is referred to as mesenchymal stem cells (MSCs) [Caplan, 1991]....
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3,651 citations
"Mesenchymal stem cells as trophic m..." refers background in this paper
...Additional complexities arise in light of recent evidence that cardiac tissue may itself contain stem cells [Beltrami et al., 2003] which could be the targets of ischemia-induced signaling, such as SDF-1, or are the targets of MSCFig....
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...Additional complexities arise in light of recent evidence that cardiac tissue may itself contain stem cells [Beltrami et al., 2003] which could be the targets of ischemia-induced signaling, such as SDF-1, or are the targets of MSC- derived signals....
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3,582 citations
"Mesenchymal stem cells as trophic m..." refers background or result in this paper
...Recent studies [Mangi et al., 2003] document the effects of transplantedMSCs expressing the pro-survival gene Akt1, and the authors recognized that the molecules released by transplanted MSCs are important....
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...Several groups studying the systemic or local administration of MSCs in cardiac repairmodels show co-localization of cardiac markers with implanted MSCs [Min et al., 2002; Shake et al., 2002;Mangi et al., 2003; Kawada et al., 2004; Nagaya et al., 2004]....
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