Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine
Reads0
Chats0
TLDR
Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state.Abstract:
Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and immunomodulatory functions that may have the greatest therapeutic impact in vivo. Unlike pharmaceutical treatments that deliver a single agent at a specific dose, MSCs are site regulated and secrete bioactive factors and signals at variable concentrations in response to local microenvironmental cues. Significant progress has been made in understanding the biochemical and metabolic mechanisms and feedback associated with MSC response. The anti-inflammatory and immunomodulatory capacity of MSC may be paramount in the restoration of localized or systemic conditions for normal healing and tissue regeneration. Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state. Safety and regulatory concerns surrounding allogeneic cell preparations make autologous and minimally manipulated cell therapies an attractive option for many regenerative, anti-inflammatory and autoimmune applications.read more
Citations
More filters
Journal ArticleDOI
Mesenchymal Stem Cells: Time to Change the Name!
TL;DR: The name of MSCs should be changed to Medicinal Signaling Cells to more accurately reflect the fact that these cells home in on sites of injury or disease and secrete bioactive factors that are immunomodulatory and trophic (regenerative) meaning thatThese cells make therapeutic drugs in situ that are medicinal.
Journal ArticleDOI
Regenerative medicine: Current therapies and future directions.
Angelo S. Mao,David J. Mooney +1 more
TL;DR: Developments in fabricating sophisticated grafts and tissue mimics and technologies for integrating grafts with host vasculature will be discussed, and directions for current and future regenerative medicine therapies are proposed.
Journal ArticleDOI
Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration
Stephen M. Richardson,Gauthaman Kalamegam,Peter Natesan Pushparaj,Csaba Matta,Adnan Memic,Ali Khademhosseini,Reza Mobasheri,Fabian L Poletti,Judith A. Hoyland,Judith A. Hoyland,Ali Mobasheri,Ali Mobasheri,Ali Mobasheri +12 more
TL;DR: This review explores the exciting opportunities afforded by MSCs and discusses the challenges associated with cartilage and IVD repair and regeneration and the optimistic view that interdisciplinary approaches will lead to significant breakthroughs in regenerating musculoskeletal tissues in the near future.
Journal ArticleDOI
MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment.
TL;DR: The current understanding of MSC exosomes is reviewed, the possible mechanisms of action in cartilage repair are discussed, and new perspectives for development of an off-the-shelf and cell-free MSC therapy for treatment of cartilage injuries and osteoarthritis are provided.
Journal ArticleDOI
Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study
Philippe Hernigou,Charles Henri Flouzat Lachaniette,J. Delambre,Sebastien Zilber,Pascal Duffiet,Nathalie Chevallier,Hélène Rouard +6 more
TL;DR: The results support the use of bone marrow-derived MSC augmentation in rotator cuff repair, especially due to the enhanced rate of healing and the reduced number of re-tears observed over time in the MSC-treated patients.
References
More filters
Journal ArticleDOI
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
Journal ArticleDOI
Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
Journal ArticleDOI
Human mesenchymal stem cells modulate allogeneic immune cell responses
TL;DR: Insight is offered into the interactions between allogeneic MSCs and immune cells and mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation.
Related Papers (5)
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more