Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
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...This has been evident with the ACT of T cells expressing TCRs to melanosomal antigens (MART-1, gp100) and to cancer testis antigens (NY ESO-1) (Chodon et al., 2014; Morgan et al., 2006; Robbins et al., 2011)....
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...Such TCRs recognize tumor antigen presented in the context of the MHC. Clinical success has been documented (Yee et al., 2015)....
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...…Weber et al., 2015) or to adoptively transfer antigen-specific T lymphocytes via ex vivo expansion of tumor-infiltrating lymphocytes (Rosenberg et al., 2011) or via administration of antigen-specific engineered T cells (via transduction with CARs or TCRs) (Beatty et al., 2014; Kalos et al., 2011)....
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...TCRs are usually cloned from TILs that are reactive to specific cancer antigens with no or very limited expression in normal adult tissue but are widely expressed by cancer cells....
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..., 2011) or via administration of antigen-specific engineered T cells (via transduction with CARs or TCRs) (Beatty et al., 2014; Kalos et al., 2011)....
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