Open AccessJournal Article
Meta-analysis: Convalescent blood products for spanish influenza pneumonia : A future H5N1 treatment? Commentary
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TLDR
To assess the potential treatment efficacy of convalescent plasma in reducing mortality in current patients with H5N1 influenza, a review of studies from the Spanish influenza era that used influenza-convalescent human blood products to treat patients with Spanish influenza complicated by pneumonia was conducted.Abstract:
Background: Studies from the Spanish influenza era reported that transfusion of influenza-convalescent human blood products reduced mortality in patients with influenza complicated by pneumonia. Treatments for H5N1 influenza are unsatisfactory, and convalescent human plasma containing H5N1 antibodies could be an effective therapy during outbreaks and pandemics. Purpose: To determine whether transfusion with influenza-convalescent human blood products reduced the risk for death in patients with Spanish influenza pneumonia. Data Sources: Manual search of English-language journals from 1918 to 1925. Citations from retrieved studies were also searched. Study Selection: Published English-language studies that had at least 10 patients in the treatment group, used convalescent blood products to treat Spanish influenza pneumonia in a hospital setting, and reported on a control or comparison group. Data Extraction: Two investigators independently extracted data on study characteristics, outcomes, adverse events, and quality. Data Synthesis: Eight relevant studies involving 1703 patients were found. Treated patients, who were often selected because of more severe illness, were compared with untreated controls with influenza pneumonia in the same hospital or ward. The overall crude case-fatality rate was 16% (54 of 336) among treated patients and 37% (452 of 1219) among controls. The range of absolute risk differences in mortality between the treatment and control groups was 8% to 26% (pooled risk difference, 21% [95% Cl, 15% to 27%]). The overall crude case-fatality rate was 19% (28 of 148) among patients who received early treatment (after <4 days of pneumonia complications) and 59% (49 of 83) among patients who received late treatment (after ≥4 days of pneumonia complications). The range of absolute risk differences in mortality between the early treatment group and the late treatment group was 26% to 50% (pooled risk difference, 41 % [Cl, 29% to 54%]). Adverse effects included chill reactions and possible exacerbations of symptoms in a few patients. Limitations: Studies were few and had many methodologic limitations. No study was a blinded, randomized, or placebo-controlled trial. Some pertinent studies may have been missed. Conclusions: Patients with Spanish influenza pneumonia who received influenza-convalescent human blood products may have experienced a clinically important reduction in the risk for death. Convalescent human H5N1 plasma could be an effective, timely, and widely available treatment that should be studied in clinical trials.read more
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Journal ArticleDOI
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Waleed Alhazzani,Morten Hylander Møller,Yaseen M. Arabi,Mark Loeb,Michelle Ng Gong,Eddy Fan,Simon Oczkowski,Mitchell M. Levy,Mitchell M. Levy,Lennie P. G. Derde,Lennie P. G. Derde,Amy L. Dzierba,Bin Du,Michael S. Aboodi,Hannah Wunsch,Hannah Wunsch,Maurizio Cecconi,Younsuck Koh,Daniel S. Chertow,Kathryn Maitland,Fayez Alshamsi,Emilie P. Belley-Côté,Emilie P. Belley-Côté,Massimiliano Greco,Matthew Laundy,Jill S. Morgan,Jozef Kesecioglu,Allison McGeer,Leonard A. Mermel,Manoj J. Mammen,Paul E. Alexander,Amy S. Arrington,John Centofanti,Giuseppe Citerio,Bandar Baw,Bandar Baw,Ziad A. Memish,Naomi E Hammond,Naomi E Hammond,Frederick G Hayden,Laura Evans,Andrew Rhodes +41 more
TL;DR: The Surviving Sepsis Campaign CO VID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19, and will provide new recommendations in further releases of these guidelines.
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