Meta-analysis in genome-wide association studies
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Cites background from "Meta-analysis in genome-wide associ..."
...fr/en/recherche/u744/igap Epilepsy and subtypes, focal and generalized(61) – ILAE – http://www....
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Cites background from "Meta-analysis in genome-wide associ..."
...sets of variants (De Bakker et al. 2008; Zeggini and Ioannidis 2009)....
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...…2008; Li et al. 2010; Marchini et al. 2007; Servin and Stephens 2007), find candidate susceptibility variants to guide fine-mapping (e.g. Liu et al. 2010), and facilitate meta-analyses that combine studies genotyped on different sets of variants (De Bakker et al. 2008; Zeggini and Ioannidis 2009)....
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"Meta-analysis in genome-wide associ..." refers background in this paper
...selection procedure we choose to employ [16, 46]....
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...If a subset of genes are taken forward for further study, we will be concerned about the proportion of them that will eventually turn out to be null, the false discovery rate (FDR) [16]....
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...The P-value from the discovery phase becomes a screening tool, which may not have its nominal type-one error rate but this is of secondary importance, as in screening we are primarily interested in the sensitivity and FDR of whatever selection procedure we choose to employ [16, 46]....
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...We should be free to use whatever methods or information will improve the FDR, so often the discovery phase will take the form of an exploration of the data in which different types of analysis are tried....
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33,234 citations
Additional excerpts
...standard random effects meta-analysis [43] applied...
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