MetaboAnalyst 3.0—making metabolomics more meaningful
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TLDR
By completely re-implementing the MetaboAnalyst suite using the latest web framework technologies, the server has been able to substantially improve its performance, capacity and user interactivity.Abstract:
MetaboAnalyst (www.metaboanalyst.ca) is a web server designed to permit comprehensive metabolomic data analysis, visualization and interpretation. It supports a wide range of complex statistical calculations and high quality graphical rendering functions that require significant computational resources. First introduced in 2009, MetaboAnalyst has experienced more than a 50X growth in user traffic (>50 000 jobs processed each month). In order to keep up with the rapidly increasing computational demands and a growing number of requests to support translational and systems biology applications, we performed a substantial rewrite and major feature upgrade of the server. The result is MetaboAnalyst 3.0. By completely re-implementing the MetaboAnalyst suite using the latest web framework technologies, we have been able substantially improve its performance, capacity and user interactivity. Three new modules have also been added including: (i) a module for biomarker analysis based on the calculation of receiver operating characteristic curves; (ii) a module for sample size estimation and power analysis for improved planning of metabolomics studies and (iii) a module to support integrative pathway analysis for both genes and metabolites. In addition, popular features found in existing modules have been significantly enhanced by upgrading the graphical output, expanding the compound libraries and by adding support for more diverse organisms.read more
Citations
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Journal ArticleDOI
MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis.
Jasmine Chong,Othman Soufan,Carin Li,Iurie Caraus,Shuzhao Li,Guillaume Bourque,David S. Wishart,Jianguo Xia +7 more
TL;DR: The user interface of MetaboAnalyst 4.0 has been reengineered to provide a more modern look and feel, as well as to give more space and flexibility to introduce new functions.
Journal ArticleDOI
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights.
Zhiqiang Pang,Jasmine Chong,Guangyan Zhou,David Anderson de Lima Morais,Le Chang,Michel Barrette,Carol Gauthier,Pierre-Étienne Jacques,Shuzhao Li,Jianguo Xia +9 more
TL;DR: The MetaboAnalyst 5.0 as mentioned in this paper is the latest version of the web-based platform for comprehensive metabolomics data analysis and interpretation, aiming to narrow the gap from raw data to functional insights for global metabolomics based on HRMS.
Journal ArticleDOI
Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis.
TL;DR: An overview of the main functional modules and the general workflow of MetaboAnalyst 4.0 is provided, followed by 12 detailed protocols: © 2019 by John Wiley & Sons, Inc.
Journal ArticleDOI
Heatmapper: web-enabled heat mapping for all
Sasha Babicki,David Arndt,Ana Marcu,Yongjie Liang,Jason R. Grant,Adam Maciejewski,David S. Wishart,David S. Wishart +7 more
TL;DR: Heatmapper is a freely available web server that allows users to interactively visualize their data in the form of heat maps through an easy-to-use graphical interface and is designed to appeal to a wide range of users.
Journal ArticleDOI
Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data Analysis.
TL;DR: This unit provides an overview of the main functional modules and the general workflow of the latest version of MetaboAnalyst (MetaboAn analyst 3.0), followed by eight detailed protocols.
References
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Journal ArticleDOI
MetaboAnalyst: a web server for metabolomic data analysis and interpretation
TL;DR: A freely accessible, easy-to-use web server for metabolomic data analysis called MetaboAnalyst, which supports such techniques as: fold change analysis, t-tests, PCA, PLS-DA, hierarchical clustering and a number of more sophisticated statistical or machine learning methods.
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