Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.
Brittany M. Angle,Rylee Phuong Do,Davide Ponzi,Richard W. Stahlhut,Bertram E. Drury,Susan C. Nagel,Wade V. Welshons,Cynthia Besch-Williford,Paola Palanza,Stefano Parmigiani,Frederick S. vom Saal,Julia A. Taylor +11 more
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For most of these outcomes non-monotonic dose-response relationships were observed; the highest BPA dose did not produce a significant effect for any outcome, but a 0.1-μg/kg/day dose of DES resulted in some but not all low-dose BPA outcomes.About:
This article is published in Reproductive Toxicology.The article was published on 2013-12-01 and is currently open access. It has received 231 citations till now. The article focuses on the topics: Adiponectin & Glucose tolerance test.read more
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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
Andrea C. Gore,Vesna A. Chappell,Suzanne E. Fenton,Jodi A. Flaws,Angel Nadal,Gail S. Prins,Jorma Toppari,R. T. Zoeller +7 more
TL;DR: A much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, can be much better translated to human health.
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Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary
TL;DR: The CEF Panel concluded that there is no health concern for any age group from dietary exposure and low health concern from aggregated exposure, although considerable uncertainty in the exposure estimates for non-dietary sources was relatively low.
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Metabolism disrupting chemicals and metabolic disorders
Jerrold J. Heindel,Bruce Blumberg,Mathew C. Cave,Ronit Machtinger,Alberto Mantovani,Michelle A. Mendez,Angel Nadal,Paola Palanza,Giancarlo Panzica,Robert M. Sargis,Laura N. Vandenberg,Frederick S. vom Saal +11 more
TL;DR: This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders.
Journal ArticleDOI
Obesity Pathogenesis: An Endocrine Society Scientific Statement
Michael W. Schwartz,Randy J. Seeley,Lori M. Zeltser,Adam Drewnowski,Eric Ravussin,Leanne M. Redman,Rudolph L. Leibel +6 more
TL;DR: The scientific goal is to elucidate obesity pathogenesis so as to better inform treatment, public policy, advocacy, and awareness of obesity in ways that ultimately diminish its public health and economic consequences.
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Non-Monotonic Dose Responses in Studies of Endocrine Disrupting Chemicals: Bisphenol a as a Case Study
TL;DR: Strong evidence is provided for NMDRCs in the EDC literature, specifically for BPA, and the current risk assessment practice where ‘safe’ low doses are predicted from high dose exposures is questioned.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Adiponectin and Adiponectin Receptors
TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
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Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses
Laura N. Vandenberg,Theo Colborn,Tyrone B. Hayes,Jerrold J. Heindel,David R. Jacobs,Duk Hee Lee,Toshi Shioda,Ana M. Soto,Wade V. Welshons,R. Thomas Zoeller,John Peterson Myers +10 more
TL;DR: It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.
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Adipocyte differentiation from the inside out.
TL;DR: Interest in adipogenesis has increased markedly over the past few years with emphasis on the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.