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Journal ArticleDOI

Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production

Tina Lütke-Eversloh, +1 more
- 01 Oct 2011 - 
- Vol. 22, Iss: 5, pp 634-647
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TLDR
The biosynthesis of the solvents 1-butanol and acetone is restricted to species of the genus Clostridium, a diverse group of Gram-positive, endospore forming anaerobes comprising toxin-producing strains as well as terrestrial non-pathogenic species of biotechnological impact.
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This article is published in Current Opinion in Biotechnology.The article was published on 2011-10-01. It has received 360 citations till now. The article focuses on the topics: Clostridium acetobutylicum & Clostridia.

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Citations
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Journal ArticleDOI

Microbial engineering for the production of advanced biofuels

TL;DR: Data-driven and synthetic-biology approaches can be used to optimize both the host and pathways to maximize fuel production, and to compete with more conventional fuels.
Journal ArticleDOI

Microbial electron transport and energy conservation - the foundation for optimizing bioelectrochemical systems.

TL;DR: This work summarizes the current knowledge on electron transport processes and uses a theoretical approach to predict the impact of different modes of transfer on the energy metabolism, which will help to optimize and advance bioelectrochemical techniques.
Journal ArticleDOI

Volatile Mediated Interactions Between Bacteria and Fungi in the Soil

TL;DR: Morphological and phenotypical alterations and reactions that occur in the organisms due to the presence of mVOCs might provide clues for elucidating the biological and ecological significance ofmVOC emissions and will help to unravel the entirety of belowground‚ volatile-wired’ interactions.
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Towards sustainable production of clean energy carriers from biomass resources

TL;DR: In this paper, the state of the art and future challenges in the recent development of biomass and associated transformation technologies for clean production of biofuels are reviewed, and a discussion of the synergistic integration of various biochemical and bioprocessing technologies is provided.
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Clostridia: the importance of their exceptional substrate and metabolite diversity for biofuel and biorefinery applications.

TL;DR: Pathway engineering to combine established substrate-utilization programs, such as for cellulose, CO2/H2 or CO, with desirable metabolic programs could lead to modular design of strains suitable for many applications.
References
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Journal ArticleDOI

Microbial cellulose utilization: fundamentals and biotechnology.

TL;DR: A concluding discussion identifies unresolved issues pertaining to microbial cellulose utilization, suggests approaches by which such issues might be resolved, and contrasts a microbially oriented cellulose hydrolysis paradigm to the more conventional enzymatically oriented paradigm in both fundamental and applied contexts.
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Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

TL;DR: This strategy uses the host’s highly active amino acid biosynthetic pathway and diverts its 2-keto acid intermediates for alcohol synthesis to achieve high-yield, high-specificity production of isobutanol from glucose.
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Acetone-butanol fermentation revisited.

D T Jones, +1 more
TL;DR: Histoire-substrats-biochimie and physiologie, facteurs favorisant le passage de the production d'acides a la production de solvents a la phase of production de Solvents, andrology and physiology, et developpement du procede.
Journal ArticleDOI

Consolidated bioprocessing of cellulosic biomass: an update.

TL;DR: Progress in developing CBP-enabling microorganisms is being made through two strategies: engineering naturally occurring cellulolytic microorganisms to improve product-related properties, such as yield and titer, and engineering non-cellulolytic organisms that exhibit high product yields and titers to express a heterologous cellulase system enabling cellulose utilization.
Journal ArticleDOI

Fermentative butanol production by clostridia

TL;DR: This article reviews biotechnological production of butanol by clostridia and some relevant fermentation and downstream processes and the strategies for strain improvement by metabolic engineering and further requirements to make fermentative butanol production a successful industrial process.
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