Metabolic Phenotyping for Enhanced Mechanistic Stratification of Chronic Hepatitis C-Induced Liver Fibrosis
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...…associated with both the clinical indices and the accumulation of 10 serum metabolites, especially L-phenylalanine and L-tyrosine, which are AAAs that play a pathogenic role in liver disease (Morgan et al., 1978; Heberer et al., 1980; Dejong et al., 2007; Gao et al., 2015; Sands et al., 2015)....
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...Using high-throughput sequencing and multi-omics strategies, we further emphasized the potential role of the gut-liver axis in the progression of liver disease through the abnormal accumulation of AAAs in the serum (Morgan et al., 1978; Heberer et al., 1980; Dejong et al., 2007; Gao et al., 2015; Sands et al., 2015)....
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...Particularly, four OTUs, OTU38 (Streptococcus), OTU124 (Veillonella), OTU224 (Streptococcus) and OTU55 (Haemophilus), were closely associated with both the clinical indices and the accumulation of 10 serum metabolites, especially L-phenylalanine and L-tyrosine, which are AAAs that play a pathogenic role in liver disease (Morgan et al., 1978; Heberer et al., 1980; Dejong et al., 2007; Gao et al., 2015; Sands et al., 2015)....
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...Unbalanced amino acid metabolism, especially high serum levels of aromatic amino acids (AAAs), including phenylalanine, tyrosine and tryptophan, is a major phenomenon indicating functional disorder in liver tissue and is critical in the pathogenesis of chronic liver diseases, including liver fibrosis, cirrhosis and HCC (Morgan et al., 1978; Heberer et al., 1980; Dejong et al., 2007; Gao et al., 2015; Sands et al., 2015)....
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...…and tryptophan, is a major phenomenon indicating functional disorder in liver tissue and is critical in the pathogenesis of chronic liver diseases, including liver fibrosis, cirrhosis and HCC (Morgan et al., 1978; Heberer et al., 1980; Dejong et al., 2007; Gao et al., 2015; Sands et al., 2015)....
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