Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
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Cites background from "Metabolic reprogramming of cancer-a..."
...IDH3α downregulation in CAFs increases HIF-1α levels (194)....
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...Particularly, CAFs from human melanomas and colon cancers, characterized by high levels of glycolytic activity, glucose uptake, lactate production, glycolytic enzyme expression and decrease of oxygen consumption, support the CAF catabolic model (194)....
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57 citations
Cites background from "Metabolic reprogramming of cancer-a..."
...metabolism and reprogramming and mitochondrial function including IDH3A (47), IDH3G, UQCRH, MRPL4 and ACADSB, as well as cellular redox regulation (GSR) (Fig....
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...1416 Molecular & Cellular Proteomics 18.7 metabolism and reprogramming and mitochondrial function including IDH3A (47), IDH3G, UQCRH, MRPL4 and ACADSB, as well as cellular redox regulation (GSR) (Fig....
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56 citations
References
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"Metabolic reprogramming of cancer-a..." refers background in this paper
...The development and progression of tumors are controlled not only by tumor cells but also by their surrounding stromal cells (Carmeliet and Jain, 2000; Rønnov-Jessen et al., 1996; Tlsty, 2001)....
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3,373 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
..., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al....
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...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al., 2005; Olaso et al., 1997)....
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1,560 citations
1,486 citations