Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Citations
47 citations
Cites background from "Metabolic reprogramming of cancer-a..."
...Increased membrane potential, mitochondrial mass and mitochondrial fatty acid oxidation (FAO) for generation of ATP and nicotinamide adenine dinucleotide were noted in CSCs with sufficient levels of oxygen [62]....
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...Different compartments may be actively proliferating regions of the tumour, with adequate levels of oxygen, hypoxic areas of the tumour, and in a distant metastatic site [45, 62]....
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46 citations
46 citations
Cites background from "Metabolic reprogramming of cancer-a..."
...Likewise, a pro-inflammatory microenvironment has been linked to the conversion of cancer toward an OXPHOS phenotype....
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...Additionally, miR-210 controls the TCA cycle by targeting iron-sulphur cluster assembly proteins (ISCU1/2), cytochrome c oxidase 10 (COX10), succinate dehydrogenase, subunit D (SDHD) or ADH dehydrogenase (ubiquinone) 1 α subcomplex, 4 (NDUFA4) in several cancers [26]. miR-378* also regulates the TCA cycle in breast cancer by inhibiting the expression of PGC-1β (peroxisome proliferator-activated receptor α, co-activator 1-α), ERRγ (estrogen-related receptor α) and GABPA (GA binding protein transcription factor, α subunit) [27]. miR-23a-mediated suppression of PGC-1α could also facilitate the metabolic shift from OXPHOS to anaerobic glycolysis to synthesise anabolic precursors to sustain proliferation of tumour cells [28]....
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...While PKM2 is expressed in embryonic, proliferating and cancer cells and promotes glycolysis, PKM1 is expressed in normal differentiated tissue and promotes OXPHOS....
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...Activated HIF1 promotes glycolysis and inhibited OXPHOS [99]....
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...PKM2 migrates into the nucleus and associates with HIF1, converting its transcriptional activity toward the regulation of OXPHOS....
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45 citations
Cites background from "Metabolic reprogramming of cancer-a..."
...GPT2 is a pyridoxal enzyme that catalyzes the reversible transamination between alanine and α-ketoglutarate to generate pyruvate and glutamate, and the effective cellular α-KG (the ratio of α-KG to fumarate and succinate) regulates dioxygenase activity (40)....
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44 citations
References
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"Metabolic reprogramming of cancer-a..." refers background in this paper
...The development and progression of tumors are controlled not only by tumor cells but also by their surrounding stromal cells (Carmeliet and Jain, 2000; Rønnov-Jessen et al., 1996; Tlsty, 2001)....
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3,373 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
..., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al....
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...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al., 2005; Olaso et al., 1997)....
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1,560 citations
1,486 citations