Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Citations
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31 citations
Cites background from "Metabolic reprogramming of cancer-a..."
...In metabolically reprogrammed CAFs, the downregulation of isocitrate dehydrogenase 3a (IDH3a) leads to a decrease in a-ketoglutarate (a-KG) and consequently decrease in the stabilization of HIF-1a protein, which in turn promotes glycolysis and inhibits oxidative phosphorylation by upregulating NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2), even under normoxic conditions.(41) Despite the precise mechanism driving the increase in glycolysis in CAFs is not fully understood, it has been demonstrated that CAFs from breast cancer patients with poor prognosis express higher levels of glycolytic enzymes....
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...Also, TGF-b1-/PDGFmediated CAF differentiation induces a decrease in the expression of Krebs cycle enzymes concomitant with an increase in glucose uptake and glycolysis.(40,41) In metabolically reprogrammed CAFs, the downregulation of isocitrate dehydrogenase 3a (IDH3a) leads to a decrease in a-ketoglutarate (a-KG) and consequently decrease in the stabilization of HIF-1a protein, which in turn promotes glycolysis and inhibits oxidative phosphorylation by upregulating NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2), even under normoxic conditions....
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29 citations
29 citations
Cites background from "Metabolic reprogramming of cancer-a..."
...(20) Role of miRNAs in CAFs conducted chemoresistance...
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...(9, 20) This review will describe miRNAs which are differential expressed between NFs and CAFs, their function in regulating fibroblasts activation as well as miRNAs expressed by CAFs as the prognostic factors in cancer....
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27 citations
Cites methods from "Metabolic reprogramming of cancer-a..."
...Foreskin fibroblasts, primary NFs and CAFs were isolated refer to described previously [30] cultured in complete Fibroblast Growth Medium-2 (Lonza)....
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...Next, we established an in vitro-induced CAF system by isolating foreskin fibroblasts and stimulating them with TGF-β and PDGF-BB to generate CAFs [30, 31]....
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References
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"Metabolic reprogramming of cancer-a..." refers background in this paper
...The development and progression of tumors are controlled not only by tumor cells but also by their surrounding stromal cells (Carmeliet and Jain, 2000; Rønnov-Jessen et al., 1996; Tlsty, 2001)....
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3,373 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
..., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al....
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...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al., 2005; Olaso et al., 1997)....
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1,560 citations
1,486 citations