Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
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Cites background from "Metabolic reprogramming of cancer-a..."
...inhibitors or even targeting CAFs’ Warburg-like metabolic profile, might suppress CAF activation (49,55,56)....
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22 citations
Cites background from "Metabolic reprogramming of cancer-a..."
...Down-regulation of IDH3amay be the hiddenmolecularmechanism of metabolic switch to aerobic glycolysis in CAFs (Zhang et al., 2015)....
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22 citations
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Cites background from "Metabolic reprogramming of cancer-a..."
...miR-424 targets Cullin 2, a scaffolding protein critical for the assembly of the ubiquitin ligase system, and downregulates isocitrate dehydrogenase-3 a (IDH3-a), which ultimately results in prolyl hydroxylase domain 2 (PHD2) inhibition and HIF-1a protein stabilization (20, 21)....
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"Metabolic reprogramming of cancer-a..." refers background in this paper
...The development and progression of tumors are controlled not only by tumor cells but also by their surrounding stromal cells (Carmeliet and Jain, 2000; Rønnov-Jessen et al., 1996; Tlsty, 2001)....
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3,373 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
..., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al....
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...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al., 2005; Olaso et al., 1997)....
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