Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
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TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
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Journal ArticleDOI
Role of adipose tissue in melanoma cancer microenvironment and progression
Elena Zoico,Elena Darra,Rizzatti,Maela Tebon,Guido Franceschetti,Gloria Mazzali,Andrea Rossi,Francesco Fantin,Mauro Zamboni +8 more
TL;DR: A dedifferentiation process of adipocytes toward fibroblast-like cells, which can promote migration of melanoma cells through activation of Wnt5a and the intracellular pathways of β-catenin and LEF-1 is hypothesized.
Journal ArticleDOI
Influence of Tumor Microenvironment and Fibroblast Population Plasticity on Melanoma Growth, Therapy Resistance and Immunoescape.
Veronica Romano,Immacolata Belviso,Alessandro Venuta,Maria Rosaria Ruocco,Stefania Masone,Federica Aliotta,Giuseppe Fiume,Stefania Montagnani,Angelica Avagliano,Alessandro Arcucci +9 more
TL;DR: In this article, the authors reviewed the features of the normal microenvironment and tumor microenvironment, and described the phenotypic plasticity of normal dermal fibroblasts and MAFs, highlighting their roles in normal skin homeostasis and TME regulation.
Journal ArticleDOI
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
TL;DR: In this paper , the authors demonstrate that the loss of GO2 disturbs redox homeostasis and halts proliferation of pancreatic ductal adenocarcinoma (PDA) cells.
Journal ArticleDOI
Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities
Dengdi Hu,Zhaoqing Li,Bin Zheng,Xi-xi Lin,Yuehong Pan,Peirong Gong,Wenying Zhuo,Yujie Hu,Cong Chen,Lini Chen,Jichun Zhou,Linbo Wang +11 more
TL;DR: A review of studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer hopes that summarizing CAF‐related studies from a historical perspective will help to accelerate the development ofCAF‐targeted therapeutic strategies for breast cancer.
Book ChapterDOI
Immune Cell Metabolism in Tumor Microenvironment.
TL;DR: This chapter introduces the updated understandings of metabolic reprogramming of immune cells in the TME and suggests new directions in manipulation of immune responses for cancer diagnosis and therapy.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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