Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
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TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
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Metabolic Interplay between Tumour Cells and Cancer-Associated Fibroblasts (CAFs) under Hypoxia versus Normoxia
Septelia Inawati Wanandi,Sri Ningsih,Hijrah Asikin,Rendy Hosea,Gladies Mercya Grameinie Neolaka +4 more
TL;DR: The role of lactate dehydrogenases (LDHs) and monocarboxylate transporters (MCTs) on the metabolic interplay between tumour cells and CAFs under hypoxia compared to normoxia is discussed.
Journal ArticleDOI
Development of a Stromal Microenvironment Experimental Model Containing Proto-Myofibroblast Like Cells and Analysis of Its Crosstalk with Melanoma Cells: A New Tool to Potentiate and Stabilize Tumor Suppressor Phenotype of Dermal Myofibroblasts
Angelica Avagliano,Maria Rosaria Ruocco,Rosarita Nasso,Federica Aliotta,Gennaro Sanità,Antonino Iaccarino,Claudio Bellevicine,Gaetano Calì,Giuseppe Fiume,Stefania Masone,Mariorosario Masullo,Stefania Montagnani,Alessandro Arcucci +12 more
TL;DR: The analysis of crosstalk between the stromal microenvironment and A375 or A2058 melanoma cells has shown that the conditioned medium of proto-myofibroblasts is cytotoxic, mainly for A20 58 cells, and dramatically reduces the migratory capability of both cell lines compared with the melanoma-control conditioned medium.
Journal ArticleDOI
Metabolic Reprogramming is a Hallmark of Metabolism Itself
TL;DR: It is argued that metabolic reprogramming is not driven by disease but instead is the main hallmark of metabolism, based on its dynamic behavior that allows it to continuously adapt to changes in the internal and external conditions.
Journal ArticleDOI
Non-coding RNAs rewire cancer metabolism networks.
TL;DR: Elucidation of how ncRNAs regulate metabolic reprogramming of cancers has opened up a novel intention to understand the mechanism of metabolic rewiring and also the opportunities of utilizing ncRNA-based therapeutics for targeting the metabolism in cancer treatment.
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Regulation of Extracellular Matrix Production in Activated Fibroblasts: Roles of Amino Acid Metabolism in Collagen Synthesis.
TL;DR: In this article, the authors summarise how fibroblasts metabolically regulate extracellular matrix (ECM) production, focussing on collagen production, at the transcriptional, translational and posttranslational level, and discuss how this can provide possible strategies for effectively targeting CAF activation and formation of a tumour-promoting stroma.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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