Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
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"Metabolic reprogramming of cancer-a..." refers background in this paper
...Hypoxia has been implicated in the metabolic reprogramming of cancer cells, and HIF-1a plays an important role in the regulation of glycolysis (Denko, 2008; Fiaschi et al., 2012; Mimura et al., 2012; Sonveaux et al., 2008)....
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"Metabolic reprogramming of cancer-a..." refers background in this paper
...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al....
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...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al., 2005; Olaso et al., 1997)....
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794 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
...The development and progression of tumors are controlled not only by tumor cells but also by their surrounding stromal cells (Carmeliet and Jain, 2000; Rønnov-Jessen et al., 1996; Tlsty, 2001)....
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792 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
...CAFs produce ECM-degrading enzymes and secrete growth factors and cytokines, which collectively promote tumor development and progression (Boire et al., 2005; Ding et al., 2010)....
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