Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Citations
2,597 citations
982 citations
648 citations
552 citations
References
722 citations
503 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
...In addition, b-hydroxybutyrate, one of the ketone bodies, increased cancer cell proliferation approximately 3-fold compared to the control group, and lactate promoted angiogenesis in tumor model (Bonuccelli et al., 2010a; Fiaschi et al., 2012)....
[...]
...Moreover, CAV1, a potential marker of CAFs in human breast cancers and associated with tumor recurrence, metastasis, and poor clinical outcome (Bonuccelli et al., 2010a; Sotgia et al., 2009), was downregulated in CAFs, whether induced or isolated, suggesting that CAV1 downregulation is a…...
[...]
454 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al....
[...]
...Through specific communications with cancer cells, CAFs directly promote tumor initiation (Bhowmick et al., 2004; Olumi et al., 1999), progression (Dimanche-Boitrel et al., 1994; Orimo et al., 2005), and metastasis (Grum-Schwensen et al., 2005; Olaso et al., 1997)....
[...]
425 citations
"Metabolic reprogramming of cancer-a..." refers background in this paper
...Hypoxia has been implicated in the metabolic reprogramming of cancer cells, and HIF-1a plays an important role in the regulation of glycolysis (Denko, 2008; Fiaschi et al., 2012; Mimura et al., 2012; Sonveaux et al., 2008)....
[...]
...In addition, b-hydroxybutyrate, one of the ketone bodies, increased cancer cell proliferation approximately 3-fold compared to the control group, and lactate promoted angiogenesis in tumor model (Bonuccelli et al., 2010a; Fiaschi et al., 2012)....
[...]
...Previous studies have shown that CAFs secrete large amounts of lactate and ketone bodies, utilized by tumor cells for anabolic metabolism or oxidative phosphorylation (Fiaschi et al., 2012)....
[...]
424 citations
"Metabolic reprogramming of cancer-a..." refers methods in this paper
...Cellular Succinate, Fumurate, and a-KG Detection The cellular content of succinate, fumurate, and a-KG were analyzed by GC-MS as previously described (Chan et al., 2009)....
[...]